(187) Long-term morbidity of offspring born to women with human immunodeficiency virus (HIV)

In a population-based retrospective cohort study, the incidence of long-term morbidity was compared between offspring born to women with or without HIV. Deliveries occurred between the years 1991 and 2021 in a tertiary medical center. The study groups were followed until 18 years of age for, respiratory, neurological, and infectious- related hospitalizations, involving a predefined set of ICD9 codes, as recorded in the hospital records. Kaplan-Meier survival curves were used to compare cumulative morbidity incidence.

Results: During the study period 356,356 deliveries were included.  76 deliveries occurred in women with HIV, of which 15% had low CD4 counts and 67% had undetectable viral load. No significant differences in long- term respiratory, neurological, and infectious, morbidities were noted between offspring born to women with or without HIV (Table). Likewise, no significant differences in cumulative incidence of long-term pediatric morbidities were noted between the groups, using Kaplan-Meier survival analyses (Figure).

Conclusion: Maternal HIV does not seem to increase the risk for long-term morbidity of the offspring.