(188) Perinatal outcomes of women with known human immunodeficiency virus (HIV)

Controversy exists regarding the association between maternal human immunodeficiency virus (HIV) and adverse perinatal outcomes. The purpose of the current study was to evaluate perinatal outcome of women with HIV.

Study Design:

In a population-based retrospective cohort study, perinatal outcome of mothers with and without HIV was compared. Deliveries occurred between the years 1991 and 2021 in a tertiary medical center. Generalized estimation equation model was used to control for confounders.

Results:

During the study period 356,356 deliveries were included, of which 76 occurred in women with HIV; 15% of these women had low CD4 counts and 67% had undetectable viral load. Women with HIV had higher rates of preterm delivery (14.5% vs. 6.9%, p=0.009) and cesarean delivery (63.2% vs. 14.0%, p< 0.001, Table 1).  Perinatal mortality was comparable between the groups (Table 1). Using generalized linear models, controlling for maternal age, maternal HIV was found to be independently associated with preterm delivery and cesarean delivery (adjusted OR 2.1, 95% CI 1.19-3.70, p=0.010 and adjusted OR 2.8, 95% CI 2.25-3.58, p< 0.001, respectively, Table 2).

Conclusion:

Maternal HIV is independently associated with preterm delivery and cesarean delivery.