This session will help non-lymphedema certified health care practitioners understand and appreciate the role of the lymphatic system with respect to edema, wound and tissue healing. The lymphatic system mediates immunity and inflammation and works in tandem with the endothelial glycocalyx to manage fluid dynamics. Dysregulation to the lymphatic system directly impacts tissue and skin health leading to lymphatic dermopathy and edema. Whether edema is clinically overt or subclinical, proper identification and management is essential for wound resolution and to improve quality of life.