WHS

WHS Session G: 2023 WOUND HEALING FOUNDATION - 3M FELLOWSHIP LECTURE

Wednesday, April 26, 2023

4:15 PM – 5:15 PM

Moderator(s)

Laura KS Parnell, BS, MS, CWS

President
Precision Consulting
Precision Consulting
Missouri City, TX

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Rivka Stone, MD, PhD

Assistant Professor
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine
Miami Beach, FL

Speaker(s)

Jordan R. Yaron, PhD

Assistant Research Professor
Arizona State University
Tempe, AZ

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Disclosure(s):

Rivka Stone, MD, PhD: No financial relationships to disclose

Jordan R. Yaron, PhD: No relevant disclosure to display

Regulation of Wound Healing by an Epidermal Serpin
Re-epithelializationinvolves a partial, transient epithelial-to-mesenchymal transition (EMT)-like state allowing epidermal keratinocytes to mobilize towards the wound bed. The precise mechanisms regulating transient epidermal EMT in wound repair remain unknown. We identified a serine protease inhibitor (serpin) that is expressed in the skin specifically upon wounding. Preliminary studies showed in vitro and in vivo wounds treated with recombinant forms of the serpin exhibit accelerated healing. This WHF 3M Fellowship funded research aims to 1) identify the cellular signaling pathways involved and 2) investigate the reparative and immunologic responses of serpin knock out mice wounds thereby identifying a potential new therapeutic target.