Discomfort Related to OnabotulinumtoxinA for Overactive Bladder: A Randomized Control Trial

Thursday, October 5, 2023

2:19 PM – 2:23 PM US PST

Location: Oregon Ballroom

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Image Label: Table 1 - Procedural Pain Outcomes

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Image Label: Table 2 - Patient Satisfaction and Symptom Improvement

Presenting Author(s)

Lia Miceli, MD (she/her/hers)

Fellow Physician
Houston Methodist Hospital
Houston, Texas, United States

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Co-Author(s)

Danielle D. Antosh, MD (she/her/hers)

Urogynecology faculty, FPMRS Division Director
Houston Methodist Hospital
Houston, Texas, United States
TN

Tariq Nisar, MPH

Statistician, Center for Health Data Science & Analytics
Houston Methodist Hospital
Houston, Texas, United States
JS

Julie N. Stewart, MD

Urology Faculty
Houston Methodist Hospital
Houston, Texas, United States
ER

Emily C. Rutledge, MD

Urogynecology Faculty
Houston Methodist Hospital
Houston, Texas, United States
RK

Rose Khavari, MD

Professor of Urology, Director of Research for the Center for Restorative Pelvic Medicine
Houston Methodist Hospital
Houston, Texas, United States

Disclosure(s):

Lia Miceli, MD: No financial relationships to disclose

Danielle D. Antosh, MD: Cook Myosite: Clinical Trial Investigator (Ongoing)

Tariq Nisar, MPH: No financial relationships to disclose

Julie N. Stewart, MD: No financial relationships to disclose

Emily C. Rutledge, MD: No financial relationships to disclose

Rose Khavari, MD: No relevant disclosure to display

This was a single-blinded, parallel randomized clinical trial of women undergoing 100 units of OnabotulinumtoxinA (BTX-A) for idiopathic overactive bladder (OAB). Patients were randomized to a 5 mL/5 injection group and a 10 mL/10 injection group with the primary outcome to evaluate procedural pain between groups. No difference was observed between groups with regards to procedural discomfort, treatment satisfaction, symptom improvement, or adverse outcomes. Treatment satisfaction and impression of improvement were very high for each group.