Expression of Cannabinoid Receptors in the Human Vagina

Thursday, October 5, 2023

2:19 PM – 2:23 PM US PST

Location: B113-116

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Image Label: Molecular Expression of CB1R and CB2R in the anterior and posterior vagina.

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Image Label: Protein Expression of CB1R and CB2R in the anterior and posterior vagina.

Presenting Author(s)

Alicia Palmieri, DO (she/her/hers)

FPMRS Fellow
Cooper University Hospital
Voorhees, New Jersey, United States

PDF

Co-Author(s)

TC

Tess Crouss, MD (she/her/hers)

Urogynecologist
Axia Women's Health
King of Prussia, Pennsylvania, United States
Jasjit K. Beausang, MD

Fellow
Cooper University Hospital
Glenside, Pennsylvania, United States
LL

Lioudmila Lipetskaia, MD

FPMRS Fellowship Program Director
Cooper University Hospital
Camden, New Jersey, United States
MD

Michael E. DiSanto, MS, PhD

Professor of Biomedical Sciences and Surgery
Cooper Medical School of Rowan University
Camden, New Jersey, United States

Disclosure(s):

Alicia Palmieri, DO: No financial relationships to disclose

Tess Crouss, MD: No financial relationships to disclose

Jasjit K. Beausang, MD: No financial relationships to disclose

Lioudmila Lipetskaia, MD: No financial relationships to disclose

Michael E. DiSanto, MS, PhD: No financial relationships to disclose

Our study aims to investigate the presence and location of cannabinoid receptor 1 (CB1R) and cannabinoid receptor 2 (CB2R) in human vaginal tissue. We found the presence of both CB1R and CB2R within the human vagina. There was a higher expression of CB2R, both on the mRNA and protein level, with relatively similar expression of both receptors throughout the vagina. These novel results may be a potential target for pharmacologic therapy for chronic pelvic pain in the future.