Novel MRI Biomarkers of Bladder Wall Composition in a Preclinical Model of Bladder Pain Syndrome

Thursday, October 5, 2023

9:08 AM – 9:12 AM US PST

Location: Oregon Ballroom

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Image Label: Figure 1. Quantitative assessment of rat bladder GAG content

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Image Label: Figure 2. T1ρ evaluation of human bladder GAG composition

Presenting Author(s)

Julie A. Suyama, MD, PhD

Fellow
University of California San Diego / Kaiser Permanente San Diego
San Diego, California, United States

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Co-Author(s)

SS

Sheronda Statum, DHA, MS

Senior Research Associate/Imaging Lab Manager
University of California San Diego
La Jolla, California, United States
AM

Aurea V.R Mohana-Borges, MD (she/her/hers)

Postdoctoral Research at University of California San Diego
University of California San Diego (UCSD)
San Diego, California, United States
YM

Yajun Ma, PhD

Assistant Professor
UC San Diego
San Diego, California, United States
JA

Jennifer Anger, MD, MPH (she/her/hers)

Professor of Urology and Vice Chair of Research
UCSD
San Diego, California, United States
CC

Christine B. Chung, MD

Professor and Executive Vice Chair
UCSD
Solana Beach, California, United States
Marianna Alperin, MD MS (she/her/hers)

Professor of Obstetrics, Gynecology and Reproductive Sciences; Professor of Urology
University of California, San Diego; Sanford Consortium for Regenerative Medicine, California, United States

Disclosure(s):

Julie A. Suyama, MD, PhD: No financial relationships to disclose

Sheronda Statum, DHA, MS: No financial relationships to disclose

Aurea V.R Mohana-Borges, MD: No financial relationships to disclose

Yajun Ma, PhD: No financial relationships to disclose

Jennifer Anger, MD, MPH: No financial relationships to disclose

Christine B. Chung, MD: No financial relationships to disclose

Marianna Alperin, MD MS: No financial relationships to disclose

Bladder pain syndrome (BPS) is a chronic, debilitating, and phenotypically heterogeneous condition that is poorly understood, underdiagnosed, and inadequately treated. Urothelial glycosaminoglycan (GAG) disruption that results in increased bladder wall permeability has been implicated in disease pathogenesis but has not been proven, and there are currently no diagnostic tests or reliable biomarkers for BPS. T1ρ is a high-resolution, non-contrast MRI technique that quantitatively assesses tissue proteoglycan content, representing a novel, non-invasive biomarker for urothelial and bladder wall GAG depletion that may facilitate diagnosis of and treatment response monitoring in patients with BPS.