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The effect of sugamadex on short-term postoperative urinary retention post-hysterectomy

Thursday, October 5, 2023

9:00 AM – 9:04 AM US PST

Location: Oregon Ballroom

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Image Label: tabe 1. Demographic characteristics of our population

Presenting Author(s)

Omar F. Duenas Garcia, MD, DHA, MPH, MS

Associate professor
West Virginia University
Morgantown, West Virginia, United States

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Co-Author(s)

TS

Twisha Shah, BS, MS (she/her/hers)

Student
West Virginia University
Morgantown, West Virginia, United States
Lf

Lexi fritts, BS (she/her/hers)

Student
West Virginia University
Martinsburg, West Virginia, United States
KL

Katherine Leung, MPH

Statistician
UMass
Worcester, Massachusetts, United States
NA

Nasser Alrayyes, BS

Medical Student
West Virginia University School of Medicine
Morgantown, West Virginia, United States
KG

Katerina Garcia, BS (she/her/hers)

Student
West Virginia University
Morgantown, West Virginia, United States
MF

Michael Flynn, MD, MHS

Division Director of Urogynecology
UMass
Worcester, Massachusetts, United States
MV

Manuel C. Vallejo, MD, DMD (he/him/his)

Associate Dean & DIO for GME, Vice Chair for Faculty Development and Institutional Affairs
West Virginia University
Morgantown, West Virginia, United States
RS

Robert Shapiro, MD, MHA

Staff
West Virginia University
morgantown, West Virginia, United States

Disclosure(s):

Omar F. Duenas Garcia, MD, DHA, MPH, MS: Applied Medical: Consultant/Advisory Board (Ongoing); Merck: Clinical Trial Investigator (Ongoing); Neomedic: Consultant/Advisory Board (Ongoing)

Twisha Shah, BS, MS: No financial relationships to disclose

Lexi fritts, BS: No financial relationships to disclose

Katherine Leung, MPH: No financial relationships to disclose

Nasser Alrayyes, BS: No financial relationships to disclose

Katerina Garcia, BS: No financial relationships to disclose

Michael Flynn, MD, MHS: No financial relationships to disclose

Manuel C. Vallejo, MD, DMD: No financial relationships to disclose

Robert Shapiro, MD, MHA: No financial relationships to disclose

Objectives: This study aimed to determine the effect of intraoperative sugammadex vs. glycopyrrolate-neostigmine (GN) for anesthesia reversal on short-term postoperative urinary retention in subjects undergoing a laparoscopic hysterectomy.

Methods: We conducted a retrospective cohort study in subjects undergoing a hysterectomy and other gynecologic procedures, including a synthetic mid-urethral sling, to compare the use of sugammadex versus GN for neuromuscular blockade reversal. We limited our analysis to synthetic slings placed by two urogynecologist surgeons. Demographics, intraoperative data, medications, and other procedures were also collected.

Results: Data was collected from 499 patient charts. Fourteen cases were excluded due to missing data. Four hundred eighty-five subjects were analyzed; 319 (65.7%) subjects received sugammadex, and 166 (34.2%) subjects received GN. There were no differences between the groups in base demographics, including age, pregnancy history, race, ethnicity, prior surgeries, type of hysterectomy, or concomitant sling. Sixty-nine subjects required a foley at discharge (14.22%). The proportion of the subjects requiring a foley who received sugammadex and GN were 11.6% and 19.3%, respectively (p 0.022). Logistic regression demonstrated that subjects receiving GN are 82% more likely to be discharged with a Foley catheter compared to the subjects who received sugammadex (OR 1.82 95% CI 1.09 to 3.05).

Conclusions: Our findings suggest that subjects receiving sugammadex for paralysis reversal were less likely to be discharged home with a Foley catheter. Prospective randomized trials are required to confirm the results of our study.