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Advances in Therapeutic Development Across Modalities

Session: Symposium: Recent Advances in Gene Therapy

Immunogenicity Assessment and Mitigation of AAV-Based Gene Therapies

Monday, April 24, 2023

9:30 AM – 10:00 AM ET

Location: Salon D, 5th Floor

Advances in Therapeutic Development

Speaker(s)

Tong-Yuan Yang, PhD (he/him/his)

Senior Scientific Director
Janssen Research & Development, LLC
Springhouse, Pennsylvania, United States

Learning Objectives:

Importance of understanding immunogenicity impact on efficacy and safety of AAV-based gene therapies
Mitigation strategies from nonclinical assessment to clinical application
Clinical manifestation associated with immunogenicity from AAV-based gene therapies
Translatability from both nonclinical and clinical mitigation strategies
Successful clinical mitigation will open the door for wider application of AAV-based gene therapies