Introduction: The origins of the American eugenics movement are rooted in the Virginia Eugenical Sterilization Act of 1924. This set a historic precedent that led to the Supreme Court ruling in Buck v. Bell (1927), which legitimized sterilization to prevent the birth of more “defective” individuals. More than 3,000 men underwent forced sterilization via vasectomy in Virginia alone. Methods: A review of historical and medical literature was undertaken, as well as analysis of academic texts on American sterilization and eugenics. Results: In the early 20th century, an increasing number of physicians promoted forced sterilization of “feebleminded” men and women to prevent the propagation of undesirable character traits in American society. One notable early proponent of eugenics was Harvey E. Jordan, dean of the School of Medicine at the University of Virginia and president of the American Genetic Association. The movement gained support from other prominent physicians including acclaimed urologist and birth control advocate William J. Robinson who wrote the early seminal books on contraception, including Eugenics, Marriage, and Birth Control in 1917. Although the first eugenic sterilization law was passed in Indiana in 1907, it was not until the Virginia Sterilization Act of 1924 that the practice of eugenic sterilization was codified as a legitimate medical practice. In its historic Buck v. Bell decision of 1927, the Supreme Court ruled that forced sterilization did not violate the 14th Amendment. The case centered around Carrie Buck in Charlottesville, VA who was deemed “defective” and “feebleminded” after being raped by the nephew of her foster parents. She was institutionalized after giving birth, and later sterilized in October 1927 as a result of the Supreme Court decision. Over the next four decades, the rate of eugenic sterilization soared nationwide. Estimates of the number of men and women undergoing forced vasectomies and salpingectomies in Virginia range from 7,300 to 8,300 between 1924 and 1979, with historical estimates of more than 60,000 sterilizations across the US. The American eugenics movement has been credited with lending inspiration to Adolf Hitler and the architects of the Holocaust. Conclusions: Virginia remained the last state to practice eugenic sterilization, repealing the statute in 1974. More than 3,000 forced vasectomies were performed in the state, and tens of thousands others across the country. The now infamous Buck v. Bell decision has yet to be overturned. Virginia Gov. Mark Warner issued a formal apology in 2002 for Virginia’s embrace of eugenics for more than five decades. SOURCE OF Funding: N/A