.jpg "Aisha L. Siebert, MD, PHD, MPH photo")
Northwestern University
Aisha Lynn Siebert, MD PhD MPH, Resident Physician, Northwestern University
My long-term research interest as a physician scientist is to operationalize genomic tools for application to personalized medicine. During my career, I plan to study genomic dysregulation in the pathogenesis of male infertility and androgen dysfunction throughout the lifespan.
My experience in gene-environment interaction and prenatal/early childhood exposures, coupled with my evolutionary genetics and epigenetics background is suited to the study of mechanisms controlling human sex determination. During my Masters training in Toxicology I utilized biostatistical and epidemiological tools to investigate gene-environment interactions. This experience introduced me to the field of Toxicology and Molecular Epidemiology, and sparked my interest in Genomic Medicine. My PhD dissertation research focused on a combined comparative genomic and metabolomic approach to study renal cellular dysfunction in a primary human cell culture model, which I developed using both evolutionary genetics and bioinformatic approaches.
I am currently completing my residency training in Urology, while concurrently applying my skills in bench research, genomics and bioinformatics to a Post-doctoral Research Fellowship developing a process for in vitro hormone-producing cell differentiation from induced pluripotent stem cells (iPSCs). The ultimate goal of this research is development of a cell-based hormonal therapy that is autologous and responsive to the hypothalamic-pituitary-gonadal axis. During this year I plan to expand my experience in developmental biology of sexual differentiation, and contribute to the understanding of genetic mechanisms regulating this process.
After completing my residency training in Urology, I plan to pursue fellowship training in Pediatric Urology with a focus on fertility and hormonal preservation/restoration. As a physician scientist I will utilize my bioinformatics skills and understanding of gene-environment interaction to study genomic regulation as it relates to male fertility, hormonal regulation, and genitourinary disease in both pediatric and adult patient populations.
Disclosure information not submitted.
Sunday, April 30, 2023
1:05 PM – 1:10 PM CST