Introduction: We aim to evaluate differences in patient-reported outcomes (PROM) using the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) questionnaire to measure patient-reported health-related quality of life (QoL) after radical prostatectomy. Methods: We retrospectively assessed prospectively collected patient-reported outcomes using EPIC-CP scores at a tertiary care center using the institutional electronic health record between 2015 and 2021 for men with prostate cancer undergoing radical prostatectomy. The primary endpoint was overall QoL scores. An imputed mixed linear regression model was used to examine the effect of covariates on the change in overall QoL scores. A pairwise comparison was used to estimate the mean QoL scores before surgery as well as 3 months, 6 months, 12 months, and 24 months after surgery for Non-Hispanic Black (NHB) and Non-Hispanic White (NHW) men. Results: Our cohort consisted of 2,229 men that answered at least one EPIC-CP questionnaire before or after surgery of which 110 (4.94%) were NHB and 2,119 (95.07%) were NHW men. The worst QoL scores were reported 3 months after radical prostatectomy with an average score of 21.52 (95%CI 19.83-23.21). The QoL scores were worse for NHB vs. NWH with a difference of (2.34, 95%CI 0.36-4.31, p=0.02) at baseline, (4.36, 95%CI 2.29-6.42, p<0.01) at 3 months after surgery, and (3.26, 95%CI 1.10-5.43, p<0.01) 6 months after surgery (Figure 1). However, there was no difference in QoL between NHB and NWH men at 12 months and 24 months after surgery. Conclusions: We found that NHB had worse QoL score than NHW men before surgery, 3 months, and 6 months after surgery. However, there was no long-term difference in reported QoL between NHB and NHW men at 12 months and 24 months after surgery. Our findings can inform preoperative counseling of men undergoing radical prostatectomy. Further research is warranted to understand the racial differences in postoperative recovery after radical prostatectomy. SOURCE OF Funding: None
