Introduction: This study aims to compare intermediate outcomes in patients following single port (SP) and multiport (MP) robotic-assisted partial nephrectomy (RAPN). Methods: This prospective, single-center study involved patients who underwent SP or MP RAPN (based on surgeon preference), performed by two surgeons between 2017 and 2022, with at least 6 months of follow-up. Linear and logistic regression analyses were performed to estimate the difference in outcomes between SP and MP, adjusting for the operating surgeon. Results: Overall, 48 patients underwent SP and 185 MP RAPN (20.6% vs. 79.4%) with minimum 6 month follow up. Table 1 summarizes demographics between the SP and MP cohorts and confirms no differences except for more females in the SP group. Table 2 summarizes the intermediate outcomes at 6 month follow up. There was no difference in disease recurrence or hernia incidence. There were significant differences in preservation of GFR (10.5, p = 0.004) despite similar changes in creatinine in the SP group. Conclusions: Based on our analyses, SP partial nephrectomy is an effective treatment with similar recurrence rates and hernia incidence at 6 months post surgery compared to MP . We did note an improvement in post op 6 month GFR for the SP group. The clinical significance of this is unclear as the change in creatinine was no different between the SP and MP groups. Larger multi-institutional studies are underway to evaluate if SP may have a protective effect on renal function. SOURCE OF Funding: None
