Introduction: Aim of our study was to assess fertility of patients treated with orchifunicolectomy for testicular cancer. Methods: A retrospective analysis of patients undergoing orchifunicolectomy for testicular cancer was conducted in three centers from 2000 to 2019. Demographic, clinical and histological characteristics of the patients were recorded. Adjuvant treatments were recorded. Number of pregnancies, number of children, cryopreservation, in vitro fertilization were recorded as well as post-operative testosterone serum level. Risk factors for pregnancy were evaluated. Univariate and multivariate analysis were performed to evaluate factors influencing pregnancy rates. Results: Overall 271 patients were enrolled with a median age of 31 (25/35) years and a median BMI of 25 (23/28 Kg/m2). Overall 187 of 271 (69%) presented a seminoma, 61 of 271 (22%) presented advanced stage (=pT2), 4 of 271 (1%) presented metastasis, 13 of 271 (5%) underwent lymphadenectomy. 112 of 271 (41%) underwent adjuvant chemotherapy and 35 of 271 (13%) underwent adjuvant radiotherapy. 71 of 271 (26%) patients had at least one child, 165 of 271 (60%) performed cryopreservation, 9 of 271 (3%) performed fertilization in vitro and out of them 8 of 9 (89%) had at least one child. Patients with at least one child presented higher levels of testosterone and performed more often in vitro fertilization (Table). On multivariate analysis testosterone levels (OR=1,94; 95%CI:1,35-2,80, p=0,001) were associated with a higher probability of having a child after testicular cancer surgery. Table 1. Patients characteristics according to Child status No Childs Childs p Patients 200 (74%) 71 (26%) Age 30 (IQR 24/36) 31 (27/34) 0,93 BMI 25 (IQR 23/28) 24 (IQR 23/27) 0,74 Serum Testosterone Level 8 (IQR 7/9) 10 (IQR 8/12) 0,01 Partner Age 25 (IQR 18/30) 27 (IQR 18 /32) 0,73 Stage T (=2) 46/200 (23%) 14/71 (20%) 0,21 Histology Seminoma Non seminoma 136 (68%) 64 (32%) 55 (78%) 16 (22%) 0,13 Limphadenectomy 10/200 (5%) 3 /71 (4%) 0,79 Chemiotherapy 85/200 (43%) 27/71 (38%) 0,51 Radiotherapy 19/200 (10%) 16/71 (22%) 0,05 Criopreservation 125/200 (63%) 40/71% (56%) 0,34 Conclusions: In our experience, patients undergoing testicular cancer surgery have 25% probability of having a child. Higher testosterone levels increase the probability of having a child in patients treated for testicular cancer. SOURCE OF Funding: No one
