Introduction: Peyronie's disease (PD) is a connective tissue disorder of the penis characterized by an abnormality in the collagen structure of the penile tunica albuginea resulting in plaque formation and penile deformity. The prevalence of PD is estimated to be 3.2-8.9% overall and as high as 20.3% in men with diabetes mellitus (DM). However, the impact of DM on PD complications is unclear. We aimed to investigate clinical correlations between DM characteristics and PD complications. Methods: We performed a retrospective study of patients with DM and PD presenting to our institution between 2007 and 2022. Clinical history, clinical parameters of DM, and PD complications were analyzed. Penile deformities were determined by physical exam, photographs, and penile Doppler ultrasound. Patients were divided into subgroups according to the onset of DM as early ( <45 years old), average (45-65 years old), and late (>65 years old). Results: A total of 185 patients were evaluated. Data collection parameters are shown in Table 1. Early onset DM correlated with the early development of PD (rho= 0.52, p<0.001). Also, early onset DM correlated with the formation of penile plaque (rho= -0.18, p=0.03) and larger plaque size (rho= -0.35, p=0.03). An increase in HbA1c level after the initial diagnosis of PD positively correlated with the formation of penile plaque (rho= 0.24, p=0.03) and penile deformity (rho= 0.24, p=0.049). Conclusions: Our study suggested that early onset DM and a further increase in HbA1c levels after the PD diagnosis significantly impact the severity of PD. Revealing the mechanisms behind these findings will help us develop better management strategies in diabetic PD patients. SOURCE OF Funding: None
