University of California Davis Sacramento, California, United States
Abstract: The arbovirus vector, Aedes aegypti, has colonized California over the past decade. Their success is facilitated by resistance to pyrethroids, the primary public health insecticide. To define the genetic responses assisting insecticide exposure recovery, we performed a high-throughput time course analysis of gene expression following sub-lethal exposure to permethrin. Results reveal enrichment of genes mediating energy metabolism and oxidative stress responses. Inhibition of these responses could be a potential target for pyrethroid synergist development.
