Abstract: For more than a decade, MosquitoMate has worked with mosquito abatement districts to develop and test novel autocidal control technologies against invasive Aedes mosquitoes, including field trials in multiple states that target Ae. albopictus and Ae. aegypti. While federal Environmental Protection Agency (EPA) approval was granted for the MosquitoMate Ae. albopictus tool in 2017, the federal permit was time limited to five years and will expire at the end of 2022. In April of 2020, MosquitoMate submitted data to the EPA requesting an extension of the permit for both additional time and an ability to operate in additional states. Concurrently, MosquitoMate submitted an application for Wolbachia infected Ae. aegypti as a mosquito suppression tool. An application to the California Department of Pesticide Regulation (CDPR) was also submitted for the Ae. aegypti tool. At the time of submitting this abstract, both applications remain under review at the EPA and CDPR. This lecture will provide an update on recent regulatory events and the status of new tools that facilitate autocidal technologies, including both Wolbachia- and non-Wolbachia control approaches.