Abstract: EPA-registered pesticide products are an important part of pest management programs to accomplish control of invertebrate public health pests. The Agency recently announced a final rule to clarify what efficacy data must be submitted to support registration of certain pesticide products. The rule, Pesticide Product Performance Data Requirements for Products Claiming Efficacy Against Certain Invertebrate Pests, codifies data requirements to support registration of products claiming efficacy against three categories of invertebrate pests: those of public health importance ( e. g., mosquitoes, ticks, cockroaches, and fleas ), wood-destroying insects ( e. g., termites ), and certain invasive invertebrate species ( e. g., Asian long-horned beetle ). These data document how well the product performs the intended function, such as knockdown or killing, against the invertebrate pest. The content and implications of the new rule for registration of products that target public health pests, such as mosquitoes and ticks, will be discussed.