Abstract: Coquillettidia perturbans is one of the most common mosquitoes collected in Massachusetts. The mosquito is an aggressive mammal biter and is implicated in the transmission of Eastern Equine Encephalitis Virus (EEEV) to humans. The larvae are notoriously difficult to control or to research because they attach themselves to emergent vegetation with a modified siphon, which allows them to extract oxygen from root tissue. Following unprecedented EEEV activity during the 2019 season across the state, aerial applications to control the larval stage of this mosquito were planned. Targeted applications to Cq. perturbans producing wetlands using Vectolex® FG (Bacillus sphaericus) and Natular® G (spinosad) were conducted. Applications occurred in both the spring and/or fall using either fixed-wing aircraft or helicopter. Different surveillance methods were employed both pre- and post-application to determine efficacy of the treatment. Evaluation of efficacy was determined by larval counts and/or adult emergence during the current season or the following year.