Vanderbilt University Medical Center Nashville, Tennessee, United States
Objective: Cardiovascular diseases (CVDs) are associated with significant mortality and morbidity. Early identification of at-risk population plays an essential role in the treatment and management of CVDs. Body mass index (BMI) is one of the easy screening tools for individuals at risk during clinic visits. Individuals with normal BMI may not get attention for early detection and prevention of CVDs. There’s are multiple reports in literature that atherogenic index of plasma (AIP) -which is log [triglyceride (mg/dL)/high-density lipoprotein cholesterol (mg/dL)], has been associated with CVDs. In this study, we will investigate the association of AIP with CVDs in individuals with normal BMI.
Methods: A sample of 6919 individuals were selected from the NHANES study population (2011-2020). The sample included all individuals in the NHANES population (2011-2020) who met the inclusion criteria (age >18 years, BMI < 25). Logistic regression analysis was performed to study the association between CVDs and AIP. Statistical analysis was adjusted for age, BMI, and diabetes status.
Results: Statistical analysis showed statistically significant association - P value < 0.05 (0.039) - between AIP and CVDs with an odds ratio of 2.1 (1.03 - 4.33).
Discussion/Conclusion: These results indicate that AIP can be used as a screening tool to identify individuals at risk for CVDs with normal BMI, which can provide cost-effective tool to help guide preventive measures. Lipid profile is a affordable and common lab test to be performed in clinic visits. Implementation of auto-calculation of AIP based on lipid profile in electronic health records will provide effective screening and monitoring tool in individuals with normal BMI.