Syndromes/Craniofacial Anomalies
Anna M. Ganios, DMD
Resident
Case Western Reserve University — UH Rainbow Babies and Children’s Hospital, Cleveland, OH
Case Western Reserve University School of Dental Medicine
University Heights, Ohio, United States
Margaret Elaine Ferretti, DMD, MPH
Program Director
Case Western Reserve University
Rainbow Babies and Children's Hospitals, Case Western Reserve University
Cleveland, Ohio, United States
Jacobsen syndrome is a rare gene deletion syndrome caused by partial deletion of chromosome 11. Clinically this syndrome is characterized by dysmorphic features, delayed development of motor skills and speech, cognitive and behavioral impairment, and congenital heart defects. This case report presents a twelve year old female with Jacobsen syndrome with unerupted permanent maxillary anterior teeth. The patient was asymptomatic. There were concerns regarding function, esthetics, and psychological development due to failure of permanent teeth eruption. The medical history is significant for bicuspid aortic valve, congenital subaortic stenosis, ventricular septal defect, coarctation of the aorta, mitral valve stenosis, and pulmonary hypertension and wheezing. Current medications include furosemide, albuterol, cetirizine, and nadolol. Patient is allergic to motrin and morphine. Clinical exam revealed unerupted teeth 6-10. However, the teeth were identified in the radiograph. This case report presents the challenges and a multidisciplinary treatment approach to facilitate care for the patient in order to obtain the best possible outcome.