Special Health Care Needs
Andrew C. Lane, MS, DMD
Resident
Oregon Health & Science University, Portland, OR
Oregon Health & Science University
Portland, Oregon, United States
Kristopher A. Kerns, Ph.D. MPH-D
University of Washington
Elizabeth Palmer, DMD MS
Oregon Health & Science University
Madeline Krieger, Ph.D.
Oregon Health & Science University
Justin Merritt, Ph.D.
Oregon Health & Science University
Jacy Stauffer, DMD
Oregon Health & Science University
Portland, Oregon, United States
Purpose: Children with Down Syndrome (DS) are prone to developing periodontal disease (PD). In this study we compare plaque samples from children with DS. For the control cohort, plaque was collected from the facial surface of a non-carious primary canine of children with an oral abscess, This comparison, in turn, will help to identify trends in the oral environment prior to or during the presentation of periodontal disease.
Methods: Six children were seen for routine dental examinations. At these visits, plaque samples were recorded from the mesial surface of the mandibular central incisor and mesial surface of the maxillary primary or permanent first molar, depending on the age of child. Two additional variables were recorded: gender assigned at birth and patient age in months. Samples were then sent for 16S rDNA V3V4 amplicon sequencing. DAdA2 and Qiime were used for taxonomic analysis.
Results: Pending data accumulation and analysis.
Conclusion: By further understanding the oral microbiome of children with Down Syndrome this will allow for improvements in their overall healthcare.