How mechanical strain regulates mandibular condylar growth and remodeling remains unclear. Current research shows that up to 70% of chondrocytes transdifferentiate into bone within the mandibular condyle. Whether this mechanism is responsive to loading of the condyle via mechanical strain has not been established. This research explores this question using a mouse model and masticatory force modification (hard vs soft diet). The results indicate that reduction of loading greatly inhibits chondrocyte proliferation and transdifferentiation into bone, thus impacting 2D and 3D growth of the mandible.
Learning Objectives:
After this lecture, attendees will be able to:
Define the role of mechanical loading on mandibular morphology.
Recognize the significance of chondrocyte transdifferentiation into bone within the condyle.
Describe how chondrocyte transdifferentiation into bone cells is responsive to mechanical strain and its implication for orthodontic treatment planning.
