Dental Public Health Resident University of California San Francisco, Tennessee, United States
Abstract: The disease burden for peridontitis is highest among racial/ethnic minority groups, particularly Mexican American individuals. Overall, 42.2% (standard error, ± 1.4) of adults 30 years or older in the United States had total periodontitis, consisting of 7.8% with severe periodontitis and 34.4% with non-severe periodontitis.Given this increase, key stakeholders need to pay particular attention to creating a diverse study population in clinical trials.
Objective To assess the prevalence of racial/ethnic minorities in periodontal Disease clinical research trials compared with White individuals.
Data Sources This meta-analysis consisted of publicly available Periodontal disease clinical trials using ClinicalTrials.gov, PubMed, and Drugs@FDA from 1994 to 2021.
Study Selection Randomized clinical trials that reported on interventions for Periodontitis and included demographic subgroups including sex and race/ethnicity.
Data Extraction and Synthesis Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 2 independent reviewers extracted study-level data for a random-effects meta-analysis. A third person served as the tiebreaker on study selection. Microsoft Excel 2016 (Microsoft Corporation) and SAS, version 9.4 (SAS Institute) were used for data collection and analyses.
Main Outcomes and Measures The primary outcomes were the prevalence of each demographic subgroup (White, Black, Hispanic/Latino, other race/ethnicity groups, and female or male) in each trial according to the trial start year, study region, and study sponsor. Participation rates are expressed as percentages.
