OC 05 - COVID Mechanisms of Thrombosis I

Moderator(s)

• DA

  Deepa Arachchillage, MD

  consultant haematologist
  Centre for Haematology
  Imperial College London
  London, England, United Kingdom
• 

  Jean Connors, MD

  Hematologist, Medical Director Hemostatic and Antithrombotic Stewardship Service
  Division of Hematology
  Brigham and Women's Hospital
  Boston, Massachusetts, United States

Presentations:

• 1:00 PM – 1:15 PM

  SARS-CoV-2 RBD and its variants can induce platelet activation and clearance: Implications for vaccinations and antibody therapy against COVID-19
  

  Co-Author: Xiaoying Ma – St. Michael's Hospital

  Co-Author: Jady Liang – St. Michael's Hospital

  Co-Author: Guangheng Zhu – St. Michael's Hospital, Keenan Research Centre

  Presenting Author: Preeti Bhoria, MSc, PhD – St. Michael's Hospital

  Co-Author: Daniel T. MacKeigan – University of Toronto

  Co-Author: Lisha Lin – St. Michael's Hospital

  Co-Author: Ziyan Chen – St. Michael's Hospital/University of Toronto

  Co-Author: Danielle Karakas – St. Michael's Hospital/University of Toronto

  Co-Author: Zhenze Liu – St. Michael's Hospital

  Co-Author: Chuanbin Shen – St. Michael's Hospital

  Co-Author: Yuchong Li – St. Michael's Hospital/University of Toronto

  Co-Author: Jiayu Dou – St. Michael's Hospital

  Co-Author: Zack Rousseau – St. Michael's Hospital/University of Toronto

  Co-Author: Hamed Shaykhalishahi – St. Michael's Hospital

  Co-Author: Jiamin Zhang – St. Michael's Hospital

  Co-Author: Tiffany Ni – St. Michael's Hospital/University of Toronto

  Co-Author: Pingguo Chen – St. Michael's Hospital

  Co-Author: Haibo Zhang – St. Michael's Hospital/University of Toronto

  Co-Author: Ori Rotstein – St. Michael's Hospital/University of Toronto

  Co-Author: Heyu Ni – St. Michael's Hospital, Keenan Research Centre
• 1:15 PM – 1:30 PM

  Proteome and phosphoproteome analyses of SARS-CoV-2-infected humanized K18-ACE2 mice reveal hyperactive phenotype of circulating platelets
  

  Presenting Author: Saravanan Subramaniam, M.Pharm, PhD – Department of Medicine, Boston University, Boston, MA, USA

  Co-Author: Ryan Matthew Hekman – Center for Network Systems Biology, Boston University, Boston, MA, USA

  Co-Author: Archana Jayaraman – Pulmonary Center, Department of Medicine, Boston University, Boston, MA, USA

  Co-Author: Aoife Kateri O'Connell – National Emerging Infectious Diseases Laboratories (NEIDL) and Department of Microbiology, Boston University, Boston, MA, USA

  Co-Author: Mary Paige Montanaro – National Emerging Infectious Diseases Laboratories (NEIDL) and Department of Pathology and Laboratory Medicine, Boston University, Boston, USA

  Co-Author: Devin Kenney – National Emerging Infectious Diseases Laboratories (NEIDL) and Department of Microbiology, Boston University, Boston, USA

  Co-Author: Maria Ericsson – Electron Microscopy Facility at Harvard Medical School, Harvard University

  Co-Author: Sarah Walachowski – Pulmonary Center, Department of Medicine, Boston University, Boston, MA, USA

  Co-Author: Benjamin Blum – Center for Network Systems Biology, Boston University, Boston, MA, USA

  Co-Author: Katya Ravid – Whitaker Cardiovascular Institute and Department of Medicine, Boston University School of Medicine, Boston, MA, USA

  Co-Author: Nicholas A Crossland – Boston University, National Emerging Infectious Diseases Laboratories (NEIDL), Boston MA, USA

  Co-Author: Florian Douam – Boston University, National Emerging Infectious Diseases Laboratories (NEIDL), Boston MA, USA

  Co-Author: Andrew Emili – Center for Network Systems Biology, Boston University, Boston, MA, USA

  Co-Author: Markus Bosmann – BU Pulmonary Center, Department of Medicine and National Emerging Infectious Diseases Laboratories (NEIDL), Boston University, Boston MA, USA; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg- University, Mainz, Germany
• 1:30 PM – 1:45 PM

  Hypoxia promotes metabolic and functional platelet exhaustion in critically ill COVID-19 patients
  

  Co-Author: Ludovica lombardi – Sapienza University of Rome

  Co-Author: Francesca Maiorca – Sapienza University of Rome

  Co-Author: Ramona Marrapodi – Sapienza University of Rome

  Co-Author: Noemi Scafa – Sapienza University of Rome

  Co-Author: Simone Cesaroni – Sapienza University of Rome

  Co-Author: Bernadette Corica – Sapienza University of Rome

  Co-Author: Giulio F Romiti – Sapienza University of Rome

  Co-Author: Patrizia Pasculli – Sapienza University of Rome

  Co-Author: Maria Rosa Ciardi – Sapienza University of Rome

  Co-Author: Franco Ruberto – sapienza university of rome

  Co-Author: Francesco Pugliese – Sapienza university of Rome

  Co-Author: Fabio M. Pulcinelli – Sapienza University of Rome

  Co-Author: Claudio Mastroianni – Sapienza University of Rome

  Co-Author: Stefania Basili – Sapienza University of Rome

  Presenting Author: Lucia Stefanini, PhD – Sapienza University of Rome
• 1:45 PM – 2:00 PM

  Biphasic thrombus formation and resolution during a coronavirus infection in the liver
  

  Presenting Author: Manuel Salzmann, PhD – Medical University of Vienna

  Co-Author: Julia B. Kral-Pointner, PhD – Medical University of Vienna

  Co-Author: Patrizia Gibler – Medical University of Vienna

  Co-Author: Johann Wojta, PhD – Medical University of Vienna

  Co-Author: Roberto Plasenzotti – Medical University of Vienna

  Co-Author: Philipp Hohensinner – Center for Biomedical Research, Medical University of Vienna
• 2:00 PM – 2:15 PM

  Endothelial cell activation, Weibel-Palade body secretion and enhanced angiogenesis in severe COVID-19
  

  Presenting Author: Ellie Karampini, PhD – Royal College of Surgeons in Ireland, RCSI Dublin

  Co-Author: Stephanie Elliott – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland

  Co-Author: Helen Fogarty, MB BAO BCh MSc MRCPI – Royal College of Surgeons in Ireland, Dublin 2, Ireland

  Co-Author: Jamie M. O'Sullivan, PhD – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

  Co-Author: Colm Bergin – St James's Hospital

  Co-Author: Cliona Ni Cheallaigh – Department of Infectious Diseases, St James’s Hospital, Dublin, Ireland.

  Co-Author: Mary Byrne – National Coagulation Centre, St James’s Hospital, Dublin, Ireland

  Co-Author: Ignacio Martin-Loeches – Department of Intensive Care Medicine, St James’s Hospital, Dublin, Ireland

  Co-Author: Patrick W. Mallon – UCD

  Co-Author: Gerard F. Curley – Royal College of Surgeons in Ireland, RCSI Dublin

  Co-Author: Siobhan Glavey – Royal College of Surgeons in Ireland, RCSI Dublin

  Co-Author: Roger J.S. Preston, PhD – Royal College of Surgeons in Ireland

  Co-Author: Soracha Ward – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland

  Co-Author: James O'Donnell – Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland