LB 01 - Late Breaking I

Moderator(s)

• 

  Robert Ariens, PhD

  Professor
  Discovery and Translational Science Department
  Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
  Leeds, England, United Kingdom
• 

  Marcel Levi, MD,PhD

  Medicine
  Netherlands Science Council, Amsterdam University Medical Center, & University College London
  Amsterdam

Presentations:

• 2:45 PM – 3:00 PM

  A Phase 3 study (ATLAS-PPX) to evaluate efficacy and safety of fitusiran, an siRNA therapeutic, in people with haemophilia A or B who have switched from prior factor or bypassing agent prophylaxis
  

  Presenting Author: Gili Kenet, MD – The National Hemophilia Center, and Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Tel Aviv, Israel

  Co-Author: Beatrice Nolan – Children's Health Ireland at Crumlin

  Co-Author: Bulent Bulent Zulfikar, MD – Istanbul University Oncology Institute

  Co-Author: Bulent Antmen – Department of Pediatric Hematology/Oncology and Bone Marrow Transplantation Unit, Faculty of Medicine, Acibadem University, Adana Hospital

  Co-Author: Peter Kampmann – Department of Hematology, Copenhagen University Hospital, Rigshospitalet

  Co-Author: Tadashi Matsushita – Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.

  Co-Author: Chur-Woo You – Department of Pediatrics, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon, South Korea

  Co-Author: Kateryna Vilchevska – “National Specialized Children's Hospital “OKHMATDYT” of the Ministry of Health of Ukraine”, Hemostasis Pathology Center

  Co-Author: Catherine N. N. Bagot, Dr MBBS MD – Department of Haematology, Glasgow Royal Infirmary, Glasgow, United Kingdom

  Co-Author: Azizan Sharif – Hospital Sultanah Aminah

  Co-Author: Flora Peyvandi, MD, PhD (she/her/hers) – Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

  Co-Author: Guy Young, MD – Children's Hospital Los Angeles

  Co-Author: Claude Negrier – Louis Pradel University Hospital, Claude Bernard University Lyon 1

  Co-Author: Ting Quan – Sanofi

  Co-Author: Stacey Poloskey – Sanofi

  Co-Author: Christian Sussebach – Sanofi

  Co-Author: Fadi Shammas – Sanofi

  Co-Author: Shauna Andersson – Sanofi

  Co-Author: Baisong Mei – Sanofi, Cambridge, MA, USA

  Co-Author: Kaan Kavakli – Ege Hemophilia Center, Izmir, Turkey
• 3:00 PM – 3:15 PM

  Concizumab Prophylaxis in Patients With Haemophilia A or B With Inhibitors: Efficacy and Safety Results From the Primary Analysis of the Phase 3 explorer7 Trial
  

  Presenting Author: Víctor Jiménez Yuste, MD PhD – La Paz University Hospital

  Co-Author: Pantep Angchaisuksiri, MD – Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

  Co-Author: Giancarlo Castaman – Center for Bleeding Disorders and Coagulation, Department of Oncology, Careggi University Hospital, Florence, Italy

  Co-Author: Katarina Cepo – Novo Nordisk A/S

  Co-Author: Jesper Haaning – Novo Nordisk A/S

  Co-Author: Sanja H. Jacobsen – Novo Nordisk A/S, Søborg, Denmark

  Co-Author: Johnny Mahlangu, MD – Haemophilia Comprehensive Care Centre, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa

  Co-Author: Tadashi Matsushita – Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.

  Co-Author: Keiji Nogami – Nara Medical University, Nara, Japan

  Co-Author: Amy Shapiro – Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA
• 3:15 PM – 3:30 PM

  Relationship between transgene-produced FVIII and bleeding rates 2 years after gene transfer with valoctocogene roxaparvovec: Results from GENEr8-1
  

  Presenting Author: Johnny Mahlangu, MD – Haemophilia Comprehensive Care Centre, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa

  Co-Author: Hervé Chambost – AP-HM, Department of Pediatric Hematology Oncology, Children Hospital La Timone & Aix Marseille University, INSERM, INRA, C2VN, Marseille, France

  Co-Author: Sheng-Chieh Chou, MD. (he/him/his) – Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital

  Co-Author: Amy L. Dunn – Nationwide Children's Hospital Division of Haematology, Oncology and Bone Marrow Transplant and The Ohio State University College of Medicine, Columbus, OH, USA

  Co-Author: Annette von Drygalski, MD – University of California San Diego

  Co-Author: Radoslaw Kaczmarek – Indiana University School of Medicine, IUPUI-Wells Center for Pediatric Research, and Hirszfeld Institute of Immunology and Experimental Therapy

  Co-Author: Gili Kenet, MD – The National Hemophilia Center, and Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Tel Aviv, Israel

  Co-Author: Michael A. Laffan, MD – Centre for Haematology, Imperial College London, London, UK

  Co-Author: Andrew D. Leavitt – Adult Hemophilia Treatment Center, University of California San Francisco, San Francisco, CA, USA

  Co-Author: Bella Madan, MD FRCP FRCPath – Guy's & St. Thomas’ NHS Foundation Trust, London, UK

  Co-Author: Jane Mason – Queensland Haemophilia Centre, Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia

  Co-Author: Johannes Oldenburg – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Margareth C. Ozelo, MD, PhD (she/her/hers) – Hemocentro UNICAMP, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

  Co-Author: Flora Peyvandi, MD, PhD (she/her/hers) – Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

  Co-Author: Doris V. Quon – Luskin Orthopaedic Institute for Children

  Co-Author: Mark T. Reding – Center for Bleeding and Clotting Disorders, University of Minnesota, Minneapolis, MN, USA

  Co-Author: Susan Shapiro, MD, PhD (she/her/hers) – Oxford University Hospitals National Health Service Foundation Trust, Oxford, UK

  Co-Author: Hua Yu – BioMarin Pharmaceutical Inc., Novato, CA, USA

  Co-Author: Tara M. Robinson – BioMarin Pharmaceutical Inc., Novato, CA, USA

  Co-Author: Steven W. Pipe, MD – University of Michigan, Ann Arbor, MI, USA
• 3:30 PM – 3:45 PM

  Efficacy, Safety, and Pharmacokinetics of Once-Weekly Efanesoctocog Alfa (BIVV001) Prophylaxis in Previously Treated Patients With Severe Hemophilia A: Results From the Phase 3 XTEND-1 Study
  

  Presenting Author: Annette von Drygalski, MD – University of California San Diego

  Co-Author: Pratima Chowdary, MD – Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free London NHS Foundation Trust, London, United Kingdom

  Co-Author: Roshni Kulkarni – Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA

  Co-Author: Sophie Susen – Centre Hospitalier Universitaire de Lille, Université de Lille, Lille, France

  Co-Author: Barbara A. Konkle, MD – University of Washington

  Co-Author: Johannes Oldenburg – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Davide Matino, MD – Department of Medicine, Division of Hematology, McMaster University, Hamilton, ON

  Co-Author: Robert Klamroth, MD, PhD – Vivantes Klinikum im Friedrichshain, Clinic for Internal Medicine Angiology and Haemostaseology

  Co-Author: Angela C. Weyand, MD – University of Michigan

  Co-Author: Victor Jimenez Yuste – Hospital Universitario de La Paz, Autónoma University

  Co-Author: Keiji Nogami – Nara Medical University, Nara, Japan

  Co-Author: Stacey Poloskey – Sanofi

  Co-Author: Bent Winding – Sobi

  Co-Author: Annemieke Willemze – Sanofi, Amsterdam, Netherlands

  Co-Author: Karin Knobe – Sanofi
• 3:45 PM – 4:00 PM

  Antiplatelet effects of inhibiting coagulation factor XI in a non-human primate model of atherosclerosis
  

  Co-Author: Helen H. Vu – Oregon Health & Science University

  Co-Author: Tia C.L. Kohs – Oregon Health & Science University

  Co-Author: Jiaqing Pang – Oregon Health & Science University

  Co-Author: Kelley R. Jordan – Oregon Health & Science University

  Co-Author: Tony J. Zheng – Oregon Health & Science University

  Co-Author: Paul Kievit – Oregon Health & Science University

  Co-Author: Jennifer Johnson – Oregon Health & Science University

  Co-Author: Michael Wallisch – Aronora, Inc.

  Co-Author: Monica T. Hinds – Oregon Health & Science University

  Co-Author: Cristina Puy – Oregon Health & Science University

  Co-Author: Christina U. Lorentz – Aronora, Inc

  Co-Author: Erick I. Tucker – Aronora, Inc

  Co-Author: David Gailani, PhD – Vanderbilt University

  Co-Author: Joseph E. Aslan, PhD – Oregon Health & Science University

  Co-Author: Joseph J. Shatzel – Oregon Health & Science University

  Co-Author: Owen J.T. McCarty, PhD, FAHA – Oregon Health & Science University

  Presenting Author: Ivan Parra-Izquierdo, PhD – Oregon Health & Science University