OC 76 - Fibrinogen & Fibrinolysis

Moderator(s)

• DD

  Dominik Draxler

  Switzerland
• 

  Lauren Poole, PhD

  Postdoctoral Research Associate
  Pathobiology and Diagnostic Investigation
  Michigan State University
  East Lansing, Michigan, United States

Presentations:

• 10:15 AM – 10:30 AM

  Functional characterization and structural modeling of DNA-aptamers targeting activated coagulation Factor XIII
  

  Presenting Author: Nasim Shahidi Hamedani, PharmD PhD – University Hospital Bonn; Institute of Experimental Haematologie and Transfusion Medicine

  Co-Author: Arijit Biswas, PD Dr (Biol) – Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn

  Co-Author: Oliver Rudan – Department of Integrated Oncology, CIO Bonn, University Hospital Bonn

  Co-Author: Carlotta Meyring – Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn

  Co-Author: Günter Mayer – Life and Medical Sciences Institute, University of Bonn

  Co-Author: Johannes Oldenburg – University Clinic Bonn AöR, Institute of Experimental Haematology and Transfusion Medicine, Bonn, Germany

  Co-Author: Jens Müller – Institute of Experimental Haematology and Transfusion Medicine, University Hospital Bonn

  Co-Author: Bernd Pötzsch – Institute of Experimental Haematology and Transfusion Medicine, University Hospital Bonn
• 10:30 AM – 10:45 AM

  A zebrafish model of dysfibrinogenemia caused by hotspot mutations in the human fibrinogen gamma chain
  

  Presenting Author: Richard J. Fish, PhD – Faculty of Medicine, University of Geneva, Switzerland.

  Co-Author: Maxime Richard – University of Geneva

  Co-Author: Marguerite Neerman-Arbez – Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland
• 10:45 AM – 11:00 AM

  Molecular Basis for the Conformational Selectivity of Thrombomodulin for TAFI or Protein C
  

  Presenting Author: Michael B. Boffa, PhD – University of Western Ontario

  Co-Author: John Ackersviller – Department of Biochemistry, University of Western Ontario

  Co-Author: Haley Marier – Department of Biochemistry, University of Western Ontario

  Co-Author: Rayane Moric – Department of Biochemistry, University of Western Ontario

  Co-Author: Hammaan Khan – Department of Biochemistry, University of Western Ontario
• 11:00 AM – 11:15 AM

  CM-352 reduces rivaroxaban-associated ICH by mechanisms dependent on MMP-10 and fibrinolysis inhibition
  

  Co-Author: Manuel Navarro-Oviedo – Cima-Universidad de Navarra

  Co-Author: Juan Marta-Enguita – Cima-Universidad de Navarra

  Co-Author: Carmen Roncal, PhD – Cima Universidad de Navarra

  Co-Author: Jose A. Rodriguez – Cima Universidad de Navarra

  Co-Author: Beatriz Zandio – Complejo Hospital de Navarra

  Co-Author: Ramón Lecumberri – Clínica Universidad de Navarra

  Co-Author: Florencio JDM Machado – Cima-Universidad de Navarra

  Co-Author: Julen Oyarzabal – Cima-Universidad de Navarra

  Co-Author: Antonio Pineda-Lucena – Cima-Universidad de Navarra

  Co-Author: Jose Antonio Páramo – Clínica Universidad de Navarra

  Co-Author: Roberto Muñoz – Complejo Hospital de Navarra

  Presenting Author: Josune Orbe, PhD – Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra
• 11:15 AM – 11:30 AM

  Clot Destabilisation by the Inclusion of Fibrin with Truncations in the αC-region
  

  Presenting Author: Helen R. mcPherson – University of Leeds

  Co-Author: Cédric Duval, PhD – University of Leeds

  Co-Author: Timea Feller, PhD – Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds.

  Co-Author: Ramzi Ajjan, PhD – University of Leeds

  Co-Author: Robert A.S Ariëns, PhD – Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom