Associate Professor
University of Pavia, Pavia
Ilaria Canobbio, PhD, Departiment of Biology and Biotechnology, University of Pavia
My principal interest is the understanding of the mechanisms supporting platelet activation and aggregation in
physiological and pathological conditions. Analysis of platelet signal transduction pathways in thrombosis and
haemostasis is critical for the identification of novel pharmacological targets for thrombotic diseases, which represent
a major cause of death in western countries. In this context, my research is focused on the following aspects: Role of
tyrosine kinases (Src family kinases, Syk, focal adhesion kinases Pyk2 and FAK) in platelet adhesion, activation,
aggregation and arterial and venous thrombosis; Contribution of different phosphatidylinositol 3-kinase (PI3K)
isoforms in platelet activation; Signal transduction pathways downstream of integrins, G protein-coupled receptors
and ITAM-bearing receptors.
I have analysed the contribution of platelets to the onset of Alzheimer’s disease. Alzheimer’s disease is
characterized by the accumulation of amyloid peptides in brain parenchyma and cerebral vessel walls. Amyloid
peptides and their precursor APP are expressed in platelets. We have recently demonstrated that platelet APP is a critical regulator of venous
thrombosis and thromboembolism. I have also demonstrated the contribution of amyloid peptides in platelet
activation and oxidative stress.
I have a master in Communication of Science and I'm in the organisation of the European Reserach Night
Sunday, July 10, 2022
6:30 PM – 7:30 PM
Monday, July 11, 2022
6:30 PM – 7:30 PM
Wednesday, July 13, 2022
9:10 AM – 9:30 AM