Bernhard Nieswandt

Professor
Institute of Experimental Biomedicine - Chair I, University Hospital Würzburg and Rudolf Virchow Center for Integrative and Translational Biomaging, University of Würzburg, Germany

Presentation(s):

• OC 10.2 - Antibody-mediated depletion of human CLEC-2 in a novel humanized mouse model

  Saturday, July 9, 2022
  1:15 PM – 1:30 PM

• PB0352 - Secretion of transforming growth factor β1 from megakaryocytes is mediated by autophagy signaling pathways

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• PB0353 - RhoB drives megakaryocyte transendothelial migration in RhoA-deficient mice

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• PB0379 - Functional expression of GFP-tagged integrin αIIb in a transgenic (knockin) mouse line

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• PB0382 - The antibody JAQ1 binds to both human and mouse GPVI but differently affect their function and in vivo depletion.

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• PB0386 - The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• PB0400 - Rac1 inhibition causes impaired GPVI signalling in human platelets through GPVI shedding and loss of PLCγ2 phosphorylation

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• PB0405 - Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to G protein-coupled receptor agonists and accelerates thrombus formation in vivo

  Sunday, July 10, 2022
  6:30 PM – 7:30 PM

• OC 41.5 - A novel and unique mechanism of αIIbβ3 regulation in platelets

  Monday, July 11, 2022
  3:45 PM – 4:00 PM

• OC 45.2 - Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation

  Monday, July 11, 2022
  3:00 PM – 3:15 PM

• OC 49.2 - Spatio-temporal control of fibrin formation by platelet glycoprotein V

  Monday, July 11, 2022
  3:00 PM – 3:15 PM

• OC 57.2 - Inversed platelet/fibrin ratio in shear-dependent thrombus formation between patients with COVID-19 and sepsis identifies subtherapeutic GPIIb/IIIa blockade as a potential therapeutic target

  Tuesday, July 12, 2022
  11:00 AM – 11:15 AM

• PB1259 - Platelet α-granule content induces endothelial damage and blood brain barrier breakdown in experimental stroke

  Tuesday, July 12, 2022
  6:30 PM – 7:30 PM

• PB1271 - Multiparameter analysis of the time-dependent roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

  Tuesday, July 12, 2022
  6:30 PM – 7:30 PM

• PB1286 - GPVI drives pulmonary inflammation by mediating platelet-neutrophil complex formation in a murine model of ARDS

  Tuesday, July 12, 2022
  6:30 PM – 7:30 PM

• OC 73.4 - Characterization of a novel anti-GPVI antibody in a humanized GP6 (hGP6KI) mouse model

  Wednesday, July 13, 2022
  11:00 AM – 11:15 AM

• OC 77.4 - Pharmacological targeting of GPV in a novel humanized mouse model to modulate thrombus formation in vivo

  Wednesday, July 13, 2022
  11:00 AM – 11:15 AM