Pamela A. Christopherson

Research Program Coordinator
Versiti Blood Research Institute

Pamela Christopherson is the central coordinator for the Zimmerman Program and co-project leader of VWF Biology research at the Blood Research Institute in Milwaukee, Wisconsin. Our research focuses on the molecular impact of VWF on clinical VWD and aims to further characterize the longitudinal changes in VWF levels and bleeding symptoms, examine linkage of genetic variations in VWD families discovered in or outside of VWF by whole genome sequencing and contrast qualitative and quantitative VWD through functional VWF assays and animal models. This project addresses multiple clinical and basic questions about VWD and how assays and clinical scoring vary over time, to better elucidate the critical mechanisms in VWD, and contrast affected with unaffected family members to further understand VWF function and mechanisms involving identified genetic changes. Through these studies we expect to gain greater insight into the disease mechanisms causing VWD.

Presentation(s):

• PB0800 - Quantitative von Willebrand factor multimer analysis in von Willebrand disease patients enrolled in the Zimmerman Program study.

  Monday, July 11, 2022
  6:30 PM – 7:30 PM

• PB0809 - Performance of the ISTH-BAT bleeding score in a population of newly diagnosed VWD in the U.S. Zimmerman Program

  Monday, July 11, 2022
  6:30 PM – 7:30 PM

• PB0810 - A novel role for subtle enhanced VWF clearance in Low VWF pathogenesis highlights limitations of VWFpp/VWF:Ag ratio assessment of clearance.

  Monday, July 11, 2022
  6:30 PM – 7:30 PM

• PB0812 - Lack of Congruent VWF Levels, Genetics, and Bleeding Symptoms in Families with a Type 1 von Willebrand Disease Diagnosis

  Monday, July 11, 2022
  6:30 PM – 7:30 PM

• PB1081 - Optimizing Variant Curation Guidelines to Improve Clinical Genetic Testing and Diagnosis of von Willebrand Disease

  Tuesday, July 12, 2022
  6:30 PM – 7:30 PM