Ruben Bierings, PhD

Principal investigator
Department of Hematology, Erasmus MC, University Medical Center Rotterdam, the Netherlands

Ruben Bierings is a Group Leader and Principal Investigator at the Erasmus MC University Medical Center Rotterdam, Netherlands. Following training in the labs of dr. Jan van Mourik and dr. Jan Voorberg at Sanquin Research in Amsterdam, he obtained his PhD from the University of Utrecht for his work on storage and secretion of Von Willebrand factor. As a CDF postdoctoral fellow in the lab of dr. Matthew Hannah and dr. Tom Carter at the National Institute for Medical Research in London (UK) he studied the role of Rab GTPases and SNARE proteins in formation and exocytosis of Weibel-Palade bodies in endothelial cells.
The Bierings lab focusses on how endothelial cells and platelets control secretion of hemostatic proteins in response to vascular injury. By studying these processes in cellular models derived from patients his group aims to understand how defects in these systems can lead to bleeding abnormalities. Since 2021 he also serves as a co-chair of the ISTH SSC on Vascular Biology.

Presentation(s):

• OC 09.3 - Differential fate of Von Willebrand factor and Von Willebrand factor propeptide following release from platelet alpha-granules

  Saturday, July 9, 2022
  1:30 PM – 1:45 PM

• SSC 11.07 - Genome Engineering in Endothelial Cells

  Sunday, July 10, 2022
  5:32 PM – 5:47 PM

• PB0797 - Restoration of VWF in Von Willebrand Disease type 3 canine ECFCs through CRISPR-Cas9 mediated gene editing

  Monday, July 11, 2022
  6:30 PM – 7:30 PM

• PB0805 - Development of Personalized CRISPR/Cas9 Based Gene Correction Therapy for Von Willebrand Disease

  Monday, July 11, 2022
  6:30 PM – 7:30 PM

• OC 53.1 - Studying VWF secretion under flow using microfluidics and patient-derived endothelial cells

  Tuesday, July 12, 2022
  10:45 AM – 11:00 AM

• OC 53.5 - Loss of Rab27A Targeting to Weibel-Palade Bodies in Endothelial Colony Forming Cells of Patients with Biallelic Mutations in the Guanine Nucleotide Exchange Factor MAP-Kinase Activating Death Domain

  Tuesday, July 12, 2022
  11:45 AM – 12:00 PM

• PB1261 - Delayed CCL26 trafficking in the secretory pathway of STX5 depleted Endothelial Cells

  Tuesday, July 12, 2022
  6:30 PM – 7:30 PM

• PB1264 - Phenotypic heterogeneity within healthy donor endothelial colony forming cells explored by morphological analysis and RNA expression profiling

  Tuesday, July 12, 2022
  6:30 PM – 7:30 PM