OC 22 - VWF: New Models and Functions

Moderator(s)

• 

  Renhao Li, PhD

  Professor of Pediatrics
  Pediatrics
  Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine
  Atlanta, Georgia, United States
• 

  Cecile Denis, PhD

  Director
  Unit 1176
  INSERM
  Le Kremlin-Bicetre, Ile-de-France, France

Presentations:

• 2:45 PM – 3:00 PM

  Angiopoietin-2 binds to Von Willebrand Factor within Endothelial Cells and after Release from Weibel Palade Bodies and mediates Von Willebrand Factor dependent angiogenesis
  

  Presenting Author: Tom McKinnon, BSc, PhD – Imperial College London

  Co-Author: Richard Starke – Imperial College

  Co-Author: Koval Smith – Imperial College

  Co-Author: Golzar Mobayen, MSc – Imperial College

  Co-Author: Koralia Paschalaki, MD, PhD – National Heart and Lung Institute, Imperial College London

  Co-Author: Anna M. Randi, MD,PhD – Imperial College London

  Co-Author: Michael A. Laffan, MD – Centre for Haematology, Imperial College London
• 3:00 PM – 3:15 PM

  Inhibition of von Willebrand factor through stabilization of the ristocetin-binding site
  

  Co-Author: Nicholas A. Arce – Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, USA

  Presenting Author: Renhao Li, PhD – Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine
• 3:15 PM – 3:30 PM

  Effects of platelet-inspired haemostatic nanoparticles on bleeding in von Willebrand disease murine models
  

  Presenting Author: Stéphanie Roullet, MD PhD – Inserm U1176 - HITh

  Co-Author: Norman Luc – Case Western Reserve University

  Co-Author: Julie Rayes – University of Birmingham

  Co-Author: Frédéric Adam – Inserm

  Co-Author: Andrew Ditto – Haima Therapeutics

  Co-Author: Emily Gahagan – Haima Therapeutics

  Co-Author: Christa Pawlowski – Haima Therapeutics

  Co-Author: Michael Bruckman – Haima Therapeutics

  Co-Author: Peter J. Lenting, PhD – Laboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixte de Recherche S1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Le Kremlin-Bicêtre, France

  Co-Author: Anirban Sen Gupta, PhD – Case Western Reserve University

  Co-Author: Cécile V. Denis, PhD – Laboratory for Hemostasis, Inflammation and Thrombosis, Unité Mixte de Recherche S1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Le Kremlin-Bicêtre, France
• 3:30 PM – 3:45 PM

  Unique humanized mouse models of von Willebrand disease to implement the need for innovative therapeutic strategies
  

  Presenting Author: Caterina Casari, PhD – Inserm U1176 - HITh

  Co-Author: Marco Heestermans – Inserm U1176 - HITh

  Co-Author: Geneviève Mc Cluskey, PhD – Inserm U1176 - HITh

  Co-Author: Ivan Peyron – Inserm U1176 - HITh

  Co-Author: Christelle Reperant – Inserm U1176 - HITh

  Co-Author: Olivier Christophe – INSERM U1176

  Co-Author: Cécile V. Denis, PhD – Inserm

  Co-Author: Peter J. Lenting, PhD – INSERM U1176
• 3:45 PM – 4:00 PM

  Allele-selective inhibition of murine von Willebrand factor in vitro and in vivo
  

  Presenting Author: Yvonne K. Jongejan, MSc – Leiden University Medical Center

  Co-Author: Richard J. Dirven – Department of Internal Medicine, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

  Co-Author: Kalina Paunovska – Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.

  Co-Author: Noa A. Linthorst – Leiden University Medical Center

  Co-Author: Elisa Schrader – Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.

  Co-Author: Kim D. van der Gouw – Department of Internal Medicine, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

  Co-Author: Annika de Jong – Department of Internal Medicine, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

  Co-Author: James E. Dahlman – Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.

  Co-Author: Bart J. M. van Vlijmen – Department of Internal Medicine, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

  Co-Author: Jeroen Eikenboom – Department of Internal Medicine, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.