OC 55 - Coagulation Factors and Anticoagulants: New Discoveries

Moderator(s)

• 

  Rinku Majumder, PhD

  Professor
  Biochemistry
  Department of Interdisciplinary Oncology, LSUHSC
  New Orleans, Louisiana, United States
• 

  Mettine Bos, PhD

  Assistant Professor
  Internal Medicine, Div. of Thrombosis and Hemostasis
  Leiden University Medical Center

Presentations:

• 10:45 AM – 11:00 AM

  Retrotransposon insertions: a challenging detection and characterization solved by long-read nanopore sequencing. Relevance in antithrombin deficiency
  

  Presenting Author: Belén de la Morena-Barrio, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Murcia, Spain

  Co-Author: Javier Cuencia-Guardiola – Departamento de Informática y Sistemas, Universidad de Murcia, CEIR Campus Mare Nostrum, IMIB-Arrixaca, Facultad de Informática, Campus de Espinardo, 30100, Murcia, Spain.

  Co-Author: Pedro Garrido-Rodríguez – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain

  Co-Author: Alba Sanchis-juan – Department of Haematology, University of Cambridge and NHS Blood and Transplant, NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK.

  Co-Author: Maria Eugenia de la Morena-Barrio, PhD – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain

  Co-Author: Rosa Cifuentes-Riquelme – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain

  Co-Author: Carlos Bravo-Pérez, MD, PhD – Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain

  Co-Author: Jose Padilla – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER, Murcia, Spain.

  Co-Author: Antonia Miñano – Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain

  Co-Author: Francisco vidal – Coagulopaties congènites. Banc de Sang i Teixits. Barcelona. Unitat de Diagnòstic i Teràpia Molecular. Vall d’Hebron Institut de Recerca, Universitat Autònoma de Barcelona (VHIR-UAB). Barcelona.

  Co-Author: María L Lozano – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain

  Co-Author: Willem H Ouwehand – Department of Haematology, University of Cambridge and NHS Blood and Transplant, NIHR BioResource, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK. Department of Haematology, University College London Hospitals, London, NW1 2BU, UK

  Co-Author: Jesualdo Tomás fernández-breis – Departamento de Informática y Sistemas, Universidad de Murcia, CEIR Campus Mare Nostrum, IMIB-Arrixaca, Facultad de Informática, Campus de Espinardo, 30100, Murcia, Spain.

  Co-Author: Javier Corral – Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer-Centro Regional de Hemodonación, Universidad de Murcia, IMIB, CIBERER Spain
• 11:00 AM – 11:15 AM

  Characterization of the Factor VIII and LRP1 Interaction Suggests a Dynamic Binding Mode with Switching of Alternative Multiple Canonical Bivalent and Non-Canonical Electrostatic Contacts
  

  Co-Author: Haarin Chun – U.S. Food and Drug Administration

  Co-Author: James H. Kurasawa – AstraZeneca

  Co-Author: Philip Olivares – U.S. Food and Drug Administration

  Co-Author: Ekaterina Marakasova – Food and Drug Administration

  Co-Author: Svetlana A. Shestopal – Food and Drug Administration

  Co-Author: Gabriela U. Hassink – GSK-Rockville Center for Vaccines Research

  Co-Author: Elena Karnaukhova – Food and Drug Administration

  Co-Author: Mary Migliorini – University of Maryland School of Medicine

  Co-Author: Juliet O. Obi – University of Maryland School of Pharmacy

  Co-Author: Ally K. Smith – University of Maryland School of Pharmacy

  Co-Author: Patrick L. Wintrode – University of Maryland School of Pharmacy

  Co-Author: Prasannavenkatesh Durai – Korea Institute of Science and Technology

  Co-Author: Keunwan Park – Korea Institute of Science and Technology

  Co-Author: Daniel Deredge – University of Maryland School of Pharmacy

  Co-Author: Dudley K. Strickland – University of Maryland School of Medicine

  Presenting Author: Andrey G. Sarafanov, PhD – U.S. Food and Drug Administration
• 11:30 AM – 11:45 AM

  Protein arginine deiminase 4 inactivates tissue factor pathway inhibitor by post-translational modification of functional arginine residues.
  

  Co-Author: Stella Thomassen – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University

  Co-Author: Bryan R. Bouwens – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University

  Co-Author: Kanin Wichapong – Department of Biochemistry, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands

  Co-Author: Dennis P.L. Suylen – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University

  Co-Author: Freek G. Bouwman – Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht

  Co-Author: Tilman M. Hackeng, PhD – Coagulation Profile, Maastricht, The Netherlands

  Presenting Author: Rory R. Koenen, PhD – Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University
• 11:45 AM – 12:00 PM

  Prothrombin Circulates in Human Plasma in Multiple Covalent Forms with Differing Activities
  

  Presenting Author: Mark Schreuder, MSc – Centenary Institute, University of Sydney

  Co-Author: Diego Butera – Centenary Institute, University of Sydney

  Co-Author: Joyce Chiu – Centenary Institute, University of Sydney

  Co-Author: Philip J. Hogg – Centenary Institute, University of Sydney