OC 57 - COVID Mechanisms of Thrombosis II

Moderator(s)

• 

  Scott Kaatz, DO, MSc

  Hospitalist
  Hospital Medicine
  Henry Ford Health
  Detroit, Michigan, United States
• 

  Mari Thomas, PhD

  Consultant Haematologist
  Haematology
  University College London Hospital

Presentations:

• 10:45 AM – 11:00 AM

  SARS-CoV-2 Spike Protein Enhanced Thrombosis is inhibited by Tipiracil in Mice
  

  Presenting Author: Wei Li, MD, PhD – Joan C. Edwards School of Medicine at Marshall University

  Co-Author: Renat Roytenberg – Joan C. Edwards School of Medicine at Marshall University

  Co-Author: Autumn DeHart – Marshall University

  Co-Author: Krista Denning – Joan C. Edwards School of Medicine at Marshall University

  Co-Author: Hong Yue – Joan C. Edwards School of Medicine at Marshall University
• 11:00 AM – 11:15 AM

  Inversed platelet/fibrin ratio in shear-dependent thrombus formation between patients with COVID-19 and sepsis identifies subtherapeutic GPIIb/IIIa blockade as a potential therapeutic target
  

  Presenting Author: Lukas J. Weiss – University Hospital Wuerzburg

  Co-Author: Maria Drayss – Institute of Experimental Biomedicine, Chair I, University Hospital Würzburg; Department of Internal Medicine I, University Hospital Wuerzburg

  Co-Author: Maximilian Zeitlhöfler – Institute of Experimental Biomedicine, University Hospital Würzburg

  Co-Author: Kristina Mott, MSc – University Hospital Wuerzburg

  Co-Author: Stefan Frantz – Department of Internal Medicine I, University Hospital Würzburg

  Co-Author: Bernhard Nieswandt – Institute of Experimental Biomedicine, University Hospital Würzburg and Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg

  Co-Author: Dirk Weismann – Department of Internal Medicine I, University Hospital Würzburg

  Co-Author: Harald Schulze, PhD – Institute of Experimental Biomedicine, Chair I, University Hospital Wuerzburg, Centre of Inherited Blood Cell Disorders, University Hospital Wuerzburg
• 11:15 AM – 11:30 AM

  Cell-based high throughput screening to identify FDA/EMA approved drugs that inhibit the endothelial pro-thrombotic switch during severe COVID19 infection
  

  Presenting Author: Daisy Jones – Imperial College London

  Co-Author: Gaye Saginc Giannoustas – Imperial College London

  Co-Author: Claire Peghaire – University of Bordeaux

  Co-Author: Daniela Pirri – Imperial College London

  Co-Author: Luca Braga – University of Trieste

  Co-Author: Edoardo Schneider – King's college London

  Co-Author: Michael Appiah, MSc – Imperial College

  Co-Author: Graeme Birdsey – Imperial College London

  Co-Author: Thomas McKinnon, BSc, PhD – Imperial College London

  Co-Author: Ryan Thwaites – Imperial College London

  Co-Author: Mauro Giacca – King's college London

  Co-Author: Anna M. Randi, MD,PhD – Imperial College London
• 11:30 AM – 11:45 AM

  Decreased DNase activity in severe COVID-19 correlates with increased circulating NET burden
  

  Presenting Author: Caroline P. Martens, MD – KU Leuven

  Co-Author: Sirima Kraisin – Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

  Co-Author: Leydi Carolina Velásquez Pereira – Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven

  Co-Author: Renaud Lavend'homme – Center for Molecular and Vascular Biology, University of Leuven, Belgium

  Co-Author: Cato Jacobs – Laboratory for Clinical Infectious and Inflammatory Disorders, UZ Leuven

  Co-Author: Lore Vanderbeke – Laboratory of Clinical Microbiology, Department of Microbiology, Immunology and Transplantation, KU Leuven

  Co-Author: Els Wauters – Department of Pneumology, UZ Leuven; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven

  Co-Author: Peter Verhamme – Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven

  Co-Author: Thilo Witsch – Invasive Cardiology, University Hospital Basel; Department of Cardiology and Angiology I, University Heart Center, Freiburg-Bad Krozingen; Faculty of Medicine, University of Freiburg, Freiburg, Germany

  Co-Author: Marc Jacquemin, MD – Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium; Department of Vascular Medicine and Hemostasis, University Hospitals Leuven, Leuven, Belgium

  Co-Author: Joost Wauters – Medical Intensive Care Unit, Department of Internal Medicine, UZ Leuven; Laboratory for Clinical Infectious and Inflammatory Disorders, Department of Microbiology, Immunology and Transplantation, KU Leuven

  Co-Author: Kimberly Martinod, PhD – KU Leuven
• 11:45 AM – 12:00 PM

  Downregulation of Thrombomodulin-Thrombin-Activated Protein C pathway as a mechanism for SARS-CoV-2 induced endotheliopathy and microvascular thrombosis
  

  Presenting Author: Shreya Agarwal, MD – Texas Children's Hospital/ Baylor College of Medicine

  Co-Author: Paula Jacobi – Texas Children's Hospital/Baylor College of Medicine

  Co-Author: Sarah Sartain – Texas Children's Hospital/Baylor College of Medicine