OC 56 - Researching the Genetic Basis for VTE

Moderator(s)

• 

  Nicola J. Mutch, PhD

  Professor
  School of Medicine, Medical sciences & Nutrition
  Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen
  Aberdeen, Scotland, United Kingdom
• Av

  Astrid van Hylckama Vlieg, PhD

  Assistant Professor
  Clinical Epidemiology
  Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
  Leiden, Zuid-Holland, Netherlands

Presentations:

• 10:45 AM – 11:00 AM

  A Cross-Ancestry Meta-Analysis of Venous Thromboembolism Genetic Associations
  

  Presenting Author: Florian Thibord – Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute

  Co-Author: Derek Klarin – Division of Vascular Surgery, Stanford University School of Medicine

  Co-Author: Daniel Chasman – Division of Preventive Medicine, Brigham and Women's Hospital

  Co-Author: Maris Teder-Laving – Institute of Genomics, University of Tartu

  Co-Author: Ellen Goode – Department of Quantitative Health Sciences, Mayo Clinic

  Co-Author: Kristian Hveem – HUNT Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology

  Co-Author: Angel Martinez-Perez – Genomics of Complex Diseases Group, Research Institute Hospital de la Santa Creu i Sant Pau, IIB Sant Pau

  Co-Author: Joseph Emmerich – Department of vascular medicine, Paris Saint-Joseph Hospital Group, University of Paris

  Co-Author: Xavier Jouven – Department of Epidemiology, Université Paris Descartes, Sorbonne Paris Cité

  Co-Author: Kaoru Ito – Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences

  Co-Author: Gabriel Cuellar Partida – 23andMe, Inc.

  Co-Author: Jeffrey Haessler – Division of Public Health Sciences, Fred Hutchinson Cancer Research Center

  Co-Author: John-Bjarne Hansen, MD, PhD – Thrombosis Research Center, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway

  Co-Author: Astrid van Hylckama Vlieg, PhD – Leiden University, Medical Center

  Co-Author: Pierre-Emmanuel Morange, MD, PhD – C2VN, INRAE, INSERM Aix-Marseille University

  Co-Author: Christopher Kabrhel – Emergency Medicine, Massachusetts General Hospital

  Co-Author: David-Alexandre Tregouet, PhD – INSERM UMR1219 Bordeaux Population Health Research Center

  Co-Author: Scott Damrauer – Corporal Michael J. Crescenz VA Medical Center

  Co-Author: Andrew D. Johnson, PhD – NHLBI

  Co-Author: Nicholas L. Smith – Department of Epidemiology, University of Washington; Department of Health Service, University of Washington; Seattle Epidemiologic Research and Information Center; Department of Veterans Affairs, Office of Research and Development, Seattle, WA 98105, USA
• 11:00 AM – 11:15 AM

  Platelet RalA/B play pivotal roles in regulation of venous thrombosis by co-ordinating P-selectin-HMGB1 interaction
  

  Presenting Author: Yong Li, PhD – Uinversity of Bristol

  Co-Author: Christ Williams – University of Bristol

  Co-Author: Borko Amulic – University of Bristol

  Co-Author: Alastair Poole – University of Bristol
• 11:15 AM – 11:30 AM

  Endothelial Overexpression of Transforming Growth Factor Beta Induced in Chronic Thromboembolic Pulmonary Hypertension
  

  Presenting Author: Magdalena L. Bochenek, PhD – Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany

  Co-Author: Kathrin Saar – Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

  Co-Author: Maliheh Nazari-Jahantigh – Institute for Prophylaxis and Epidemiology of Cardiovascular Diseases, Clinic of the University of Munich, Germany

  Co-Author: Christoph Wiedenroth – Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany

  Co-Author: Mareike Lankeit – Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany

  Co-Author: Thomas Münzel – Center for Cardiology - Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany

  Co-Author: Eckard Mayer – Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany

  Co-Author: Stefan Guth – Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany

  Co-Author: Andreas Schober – Institute for Prophylaxis and Epidemiology of Cardiovascular Diseases, Clinic of the University of Munich, Germany

  Co-Author: Norbert Hübner – Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

  Co-Author: Stavros Konstantinides – Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University

  Co-Author: Katrin Schäfer, MD – University Medical Center Mainz, Mainz, Germany
• 11:30 AM – 11:45 AM

  Targeted panel sequencing for identifying new rare genetic variants associated with venous thromboembolism (VTE): application to 128 patients with unprovoked VTE and negative thrombophilia screening
  

  Presenting Author: Pierre Suchon, MD PhD – Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France; Laboratory of Haematology, La Timone Hospital, Marseille, France

  Co-Author: Noémie Saut – Laboratory of Haematology, La Timone Hospital, Marseille, France

  Co-Author: Marie-Christine Alessi, MD – Aix Marseille Université

  Co-Author: David-Alexandre TREGOUET, PhD (he/him/his) – Bordeaux Population Health research center - INSERM UMR1219

  Co-Author: Pierre-Emmanuel Morange, MD, PhD – Aix-Marseille Univ, INSERM, INRAE, C2VN, Laboratory of Haematology, Hôpitaux de Marseille, Marseille, France
• 11:45 AM – 12:00 PM

  Insight into genetic predisposition to high plasma levels of Factor VIII (FVIII) and von Willebrand Factor (vWF) in a family with venous thrombosis.
  

  Presenting Author: Silvia Spena, PhD, board certified specialist in Medical Genetics – Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, and Luigi Villa Foundation, Milan, Italy

  Co-Author: Andrea Cairo – Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center

  Co-Author: Francesca Gianniello – Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy

  Co-Author: Emanuela Pappalardo – Università degli Studi di Milano, Department of Pathophysiology and Transplantation and Fondazione Luigi Villa, Milan, Italy

  Co-Author: Mimosa Mortarino – Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, and Luigi Villa Foundation, Milan, Italy

  Co-Author: Isabella Garagiola – Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan

  Co-Author: Ida Martinelli – Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, and Luigi Villa Foundation, Milan, Italy

  Co-Author: Flora Peyvandi, MD, PhD (she/her/hers) – Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy