Blood Beijing Children's Hospital BeiJing, Beijing, China (People's Republic)
Background: Primary immune thrombocytopenia (ITP) is the most common clinical bleeding disease in children. Scientific and standardized diagnosis and treatment are of great clinical significance for children with ITP. High-quality evidence-based guidelines have important guiding significance for the standardized diagnosis and treatment of clinical childhood ITP.
Aims: To evaluate the quality of clinical practice guidelines related to the diagnosis and treatment of childhood primary immune thrombocytopenia.
Methods: Guided by the ADAPTE method of adapting the guideline, we searched PubMed, Embase, CNKI, Wanfang Database, VIP Database, China Biomedical Literature Database and Medlive (http://guide.medlive.cn), UpToDate(https://www.uptodate.com/contents/search), Practice Guideline Registry Platform(http://www.guidelines-registry.cn). The search time limit is from the establishment of the database to May 2020. Apply the Clinical Guideline Research and Evaluation System II (AGREE Ⅱ) to evaluate the quality of the included ITP guidelines.
Results: 19 guides in the past 10 years were included and evaluated by 2 researchers using AGREE Ⅱ tools. The overall quality of the 19 guides is not high. The domain called Clarity of Presentation has the highest average score of 79.68% in each domain, while the " Stakeholder Involvement" domain has the lowest average score of 23.68%. Three of the guidelines have high overall quality and scores higher than 70% in the domain called Rigour of Development.
Conclusion(s): The average quality of the included guidelines is low. At present, there is a lack of high-quality evidence-based guidelines for the diagnosis and treatment of childhood ITP in China.
