PB0010 - Overexpression of FXII as a risk of thrombosis in patients with SAMTER syndrome, angioneurotic edema, and its association with smoking rate and hematological parameters.

Background: SAMTER syndrome (SSx), with its triad bronchial asthma, nasal polyps and aspirin allergy; It is an entity that must be recognized since many patients with asthma may have other risk factors for thrombotic events, complicating the use of antiplatelet therapy. In the world we only find 5 clinics that study SSx, in addition, a strong association between angioneurotic edema, SSx and an over-expression of coagulation FXII has been found.

Aims: To study in our SAMTER clinic the expression of FXII in patients who have developed a picture of angioedema and assess their risk of thrombosis.

Methods: A cohort of 20 patients with SxS was studied, with manifestations of angioneurotic edema secondary to aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), whose clinical history, search for thrombosis factors, samples were taken for the measurement of blood count (baseline and follow-up) and FXII factor. Patients were classified as hyperactive and with normal levels of FXII. Descriptive statistics were performed on quantitative variables and frequency measurements on qualitative variables. Clinical history and hematological parameters were compared between the two study groups.

Results: A total of 21 patients were studied, 6 men and 15 women, 38% (8) were classified as hyperactive to FXII, while 71% (15) were smokers.
A strongly significant association was found between smoking rate and Hyperactivity to FXII, with respect to hematological variables: Erythrocytes hemoglobin, hematocrit and lymphocytes showing an increase in their average in hyperactives compared with those not hyperactive to FXII.

Conclusion(s): There is a strong association between smoking rate, hematocrit, hemoglobin and erythrocytes and factor XII hyperactivity in a small cohort of patients with SAMTER syndrome and angioneurotic edema.