VPB0680 - Evaluating factors that influence the joint health status of Nigerians with moderate and severe Haemophilia (WBDR Research Support Program )

Monday, July 11, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

Theresa U. Nwagha, MPH,FMCPatg

Consultant Haematologist
University of Nigeria , College of Medicine Ituku Ozalla Campus
Enugu, Enugu, Nigeria

Co-Author(s)

HO

Helen Chioma Okoye, FMCPath, FWACP

Consultant
Department of Haematology and Immunology, College of Medicine, University of Nigeria Ituku Ozalla Campus Enugu, Nigeria
Enugu, Enugu, Nigeria
NI

Nneka Iloanusi

Senior Lecturer
College of Medicine University of Nigeria Ituku Ozalla
Enugu, Enugu, Nigeria
AN

Amaka Nnamani

Senior Lecturer
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria
NC

Nnenna Chigbo

HTC comprehensive care team
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria
CK

Clara Kela-eke

HTC comprehensive care team
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria
OO

Onochie Obodo

HTC comprehensive care team
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria
NO

Nnenna Ogbodo

HTC comprehensive care team
University Teaching Hospital Ituku Ozalla
Enugu, Enugu, Nigeria
Iu

Ifeanyi uwaegbuonu

HTC comprehensive care team
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria
Co

Chidiogo ojinnaka

HTC comprehensive care team
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria
AI

Adaobi Ilo

HTC comprehensive care team
University of Nigeria Teaching Hospital
Enugu, Enugu, Nigeria

Background: Joint bleeds is a major hallmark of Haemophilia. The resultant joint damage lead to physical and functional defects which affects the overall quality of life

Aims: This study examined whether age, age of first joint bleed, annualized bleeding rates (ABR) and Qol influenced joint health status in moderate and severe haemophilia

Methods: A cross sectional single-center study involving persons with moderate(MH) and severe Haemophilia (SH) in Enugu Southeast Nigeria. Joint health status was evaluated using HJHS ( 0-124, optimum score 0) Pettersson score (which grades findings on the radiograph, max 13 points), and Universal simplified ultrasound system(us-us) (which grades findings on ultrasonography, max 14 points). Qol was assessed using ED -5D-5L questionnaire, medical notes, and WBDR were also reviewed.

Results: We report 31 patients, mean age 10 years( SD 2, range 1-39). The majority, 97% were HA. Sixty-five percent were MH and SH was 35%. Age at diagnosis was 3 years ( SD 2, range 3-15), age at first joint bleed was 20 months ( SD 3, range 1-190 months) and the mean ABR was 9 ( SD 4, range 1-40). The mean us-us score was 3 (SD 2 range 1-13). The total mean HJHS was 16 (SD 2, range 3- 56) and Pettersson's score was 8 (SD 1 range 4-18) with a significant moderate correlation between them ( r=0.44 p 0.01). The mean EQ-5D-5L score was 2 (SD 2 range 1-7) with a significant moderate correlation with HJHS( r=0.5 p, 0.03). Higher HJHS was seen in MH ( P 0.04). Age of PWH and the ED-5D-5L score were predictors of haemophilia joint health score.

Conclusion(s): The current joint health status for Nigerians with MH and SH was of moderate severity. Age of PWH and EQ-5D-5L score were predictors of HJHS. We suggest early routine joint assessment for persons with moderate to severe haemophilia.