PB0976 - CTPA in pregnant women with suspected pulmonary embolism: effect on neonatal thyroid function

Monday, July 11, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: In-Person

Presenting Author(s)

Marc Righini, MD

MD
Division of Angiology and Hemostasis, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland
Geneve, Geneve, Switzerland

Co-Author(s)

AE

Antoine Elias

Staff Physician
Nice University Hospital
Nice, Provence-Alpes-Cote d'Azur, France
OS

Olivier Sanchez

MD, PhD
Georges Pompidou European Hospital, Paris, France
Paris, Ile-de-France, France
JS

Jeannot Schmidt

Head
Clermont-Ferrand University Hospital
Clermont-ferrand, Auvergne, France
DA

Drahomir Aujesky

Head
Insel University Hospital
Bern, Bern, Switzerland
PR

Pierre-Marie Roy

Head
Angers University Hospital
Angers, Centre, France
GM

Guy Meyer

MD
Service de Pneumologie et de Soins Intensifs, Hôpital Européen Georges Pompidou, AP-HP; INSERM UMR S 970, Université de Paris, Paris; FCRIN INNOVTE, France.
Paris, Ile-de-France, France

Background: Neonatal hypothyroidism is often raised as a potential concern for the use of Computed Tomography Pulmonary Angiography (CTPA) in pregnant women with suspected PE.

Aims: To assess the incidence of hypothyroidism among newborns from mothers exposed to CTPA.

Methods: Pregnant women with clinically suspected PE, included in a multicentre multinational prospective diagnostic management outcome study, based on pretest clinical probability assessment, high-sensitivity D-dimer testing, bilateral lower limb venous compression ultrasonography, and computed tomography pulmonary angiography (CTPA). Results of the Guthrie tests were systematically collected for newborns of all women who required CTPA as part of the diagnostic strategy. A TSH level above 15 U/ml was used to define hypothyroidism.

Results: Out of the 166 women included in the Swiss participating centers, 149 underwent a CTPA including 14 with twin pregnancies. Eight women suffered a pregnancy loss and results of the Guthrie could not be retrieved for 4 newborns. All Guthrie levels were reported as being below 15 U/ml. The incidence of neonatal hypothyroidism was 0/151 (0.0%, 95% CI: 0.0-2.5%).

Conclusion(s): We did not identify any case of neonatal hypothyroidism in our cohort of 149 pregnant women investigated for suspected PE using a CTPA. Along with previous literature data, this provides further reassuring data regarding the use of CTPA in this indication.