VPB1390 - Common risk factors for arterial and venous thrombosis and the recurrence rate in young non-pregnant women

Background: The identification of common thrombotic risk factors seems important for evaluation the overall hypercoagulation status and prognosis.

Aims: To determine factors associated with arterial and/or venous thrombosis and the recurrence rate of thrombosis in non-pregnant women aged 18-44 years.

Methods: 319 women referred to the antithrombotic centre from 2010 to 2020 were enrolled in case-control study: 134 patients with first verified arterial and/or venous thrombosis and 185 women without thrombosis. Exclusion criteria: pregnancy and 6 weeks after delivery at the time of the first thrombosis; mental disorders. The demographic, clinical, laboratory and treatment characteristics were recorded. The prospective observation with median time 52 months (range from 1 to 10 years) was carried out for cases.

Results: In cases 100 women (74.6%) had venous (83 - VTE; 17 - other localizations) and 33 (24.6%) - arterial thrombosis (30 - ischemic stroke, 3 - myocardial infarction). One patient with antiphospholipid syndrome had pulmonary embolism with renal artery thrombosis. In multiple regression analysis significant common determinants for the first thrombosis were: gallbladder diseases (OR - 12; 1 95% CI 2.5 - 67.5), cardiovascular diseases (OR = 10.2; 95% CI 3.6-29.1); total cholesterol level (OR = 7.7; 95% CI 4.4 - 13.5); respiratory diseases (OR = 3.7; 95% CI 1.0-11.5); the use of combined hormonal contraceptives (OR = 3.4; 95% CI 1.7-6.8); varicose veins of the lower extremities (OR = 2.5; 95% CI 1.0-4.9). At follow-up, 12 women (8, 95 %) had a recurrence of thrombosis: 8 - VTE; 3 - ischemic strokes, 1 - cerebral vein thrombosis).

Conclusion(s): Independent common factors, associated with arterial and venous thrombosis in young non-pregnant women were gallbladder diseases, cardiovascular diseases; total cholesterol level, respiratory diseases, the use of combined hormonal contraceptives and varicose veins of the lower extremities. The recurrence rate was 8, 95% during follow-up on average for 4.3 years.