junior researcher FSBEI HE PRMU of Ministry of Health of Russia nizny novgorod, Nizhegorod, Russia
Background: A significant role in disorders of blood microcirculation is played by changes in the functional activity of the hemostasis system, the determination of which is especially important in the prepubertal, pubertal and postpubertal periods regardless of the sex of the child.
Aims: To study the functional properties of platelets and hemostasis in practically healthy children of different age groups.
Methods: The blood of age groups was used: 10 children - up to 6 years old inclusive, 10 children - 7-11 years old, 10 children - 12-16 years old, 35 people - 17 years old and older. In children’s blood were determined: platelet aggregation and activation, content of SFMC, activity of VWF, thromboelastography. Spearman's correlation was used. The results of study were processed using the Mann-Whitney criteria.
Results: A trend of increased flow-induced aggregation and activation was revealed with increasing age. Children under of 6 years and 7-11 years had the lowest values of the degree and rate of these processes (40% decrease compared to 17 years, p< 0.05 and p< 0.001, respectively). The degree and rate of these processes in 12 years did not differ from parameters in 17 years. At the age to 11 years old had the lowest values of the RFMC level and VWF activity (a decrease of 30% compared to 17 years, p< 0.05). Сorrelations between the studied indicators only at 17 years fixed – between the level of SFMC and the degree of platelet activation (r = -0.81) and with the rate of their aggregation (r = 0.60), between the activity of VWF and the parameter R of the thromboelastogram (r = - 0.90).
Conclusion(s): Thus, the functional properties of platelets and plasma hemostasis change in healthy children during ontogenesis.
