VPB1117 - Diagnostic Value Of Tromboelastography Using Korean Society On Thrombosis And Haemostasis Criteria On Disseminated Intravascular Coagulation Induced Sepsis Patients

Background: Sepsis patients with DIC have a higher mortality, which is 43%, compared to sepsis patients without DIC which is 27%. Early diagnosis is important to support the success of DIC therapy.
Conventional coagulation tests have many limitations. TEG is used to provide precise information to treat hemostasis disorders. This method can overcome several limitations in conventional coagulation tests.

Aims: To prove TEG can be used to diagnose sepsis patients with overt DIC at the Saiful Anwar General Hospital Malang Indonesia

Methods: This cross sectional study was carried out at the ICU of Saiful Anwar Hospital in the April-September 2019 period. This study has been approved by the ethics committee of Saiful Anwar Hospital. Patients with a diagnosis of sepsis received blood samples for platelet count, PT, aPTT, Fibrinogen, D-Dimer and TEG parameters. DIC scoring applies based on KSTH criteria as gold standard. Patients are considered to have overt DIC if the KSTH score ≥ 3 and non-overt DIC if the KSTH score < 3.The significance of difference among groups was tested using unpaired t-test. ROC curve was made to produce optimal cutoff, sensitivity value, and specificity. Statistical analysis was performed with SPSS version 23.0.

Results: The number of study subjects was 46 people. 54,55% of sepsis group with overt DIC was male. The mean age in the DIC overt group was 53 years. Comparative test results were different (p < 0.05) in all parameters except age, fibrinogen and D-Dimer. TEG parameter test results consisting of r time, k time, ⍺ angle, MA, and CI showed AUC 0,816; 0,874; 0,878; 0,899 and 0,935,respectively.

Conclusion(s): The diagnostic value of TEG in direct diagnosis of DIC shows good AUC, sensitivity and specificity, so it is important to note its use.