PB1332 - Cerebral venous thrombosis: clinical, radiological, biological and etiological characteristics of a French Prospective Cohort: Comparison with ISCVT cohort

Background: Cerebral venous thrombosis (CVT) is a rare disease with highly variable clinical presentation and outcome. Etiological assessment may be negative. T. The mechanisms involved in this variability remain unknown.

Aims: The aim of this multicenter French study registered on ClinicalTrials.gov (NCT02013635) was therefore to prospectively recruit a cohort of patients with cerebral venous thrombosis (FPCCVT) in order to study thrombin generation and clot degradation and to evaluate their influence on clinical radiological characteristics.

Methods: This prospective, multicenter, French study was conducted from July 2011 to September 2016. Consecutive patients (aged >15 years) referred to the stroke units of 21 French centers and who had a diagnosis of symptomatic CVT were included.
The diagnosis of CVT had to be confirmed by imaging. Clinical, radiological, biological and etiological characteristics were recorded at baseline, at acute phase, at 3 months and at last follow-up visit. Thrombophilia screening and the choice of treatment were performed by the attending physician. All data were compared with data from the International Study on CVT..

Results: Two-hundred-and-thirty-one patients were included: 117 (50.6%) had isolated intracranial hypertension, 96 (41.5%) had focal syndrome. During hospitalization, 229 (99.1%) patients received anticoagulant treatment. Median length of hospital stay was 10 days. Five patients died during hospitalization (2.2%). At 3 months, 216 patients (97.0%) had follow-up with neurological data based on an outpatient visit. The mean duration of antithrombotic treatment was 9 months and the mean time to last follow-up was 10.5 months. At the end of follow-up, 8 patients had died and 26 patients were lost to follow-up. At least one risk factor was identified in 200 patients.

Conclusion(s): We demonstrated that the FPCCVT cohort had characteristics similar to the historical ISCVT cohort. Nevertheless, the initial clinical presentation was less severe in our study probably due to an improvement in diagnostic methods between the two studies.