VPB0633 - Adipokines and insulin resistance in young individuals with various metabolic phenotypes

Monday, July 11, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

Vasilii Chulkov, MD

professor of Faculty Therapy Department South-Ural state medical university, Russia, Chelyabinsk
professor of Faculty Therapy Department South-Ural state medical university, Russia, Chelyabinsk
Chelyabinsk, Sverdlovsk, Russia

Co-Author(s)

VC

Vladislav Chulkov

associate professor of Faculty Therapy Department
South-Ural state medical university, Russia, Chelyabinsk
Chelyabinsk, Sverdlovsk, Russia
Natalia K. Vereina, D.Sc. (Medicine)

professor
South Ural State Medical Universiry
Chelyabinsk, Sverdlovsk, Russia
EG

Elena Gavrilova

associate professor of Policlinic Therapy and Clinical Pharmacology Department
South Ural State Medical Universiry
Chelyabinsk, Sverdlovsk, Russia
EL

Elizaveta Lenets

resident of Faculty Therapy Department
South Ural State Medical Universiry
Chelyabinsk, Sverdlovsk, Russia
EP

Ekaterina Pankova

graduate student of Faculty Therapy Department
South Ural State Medical Universiry
Chelyabinsk, Sverdlovsk, Russia
SM

Sergei Martynov

graduate student of Faculty Therapy Department
South Ural State Medical Universiry
Chelyabinsk, Sverdlovsk, Russia
SS

Sergei Sinitsin

Head of Faculty Therapy Department
South Ural State Medical Universiry
Chelyabinsk, Sverdlovsk, Russia

Background: Dysregulation of certain adipokines can promote pathogenic conditions associated with insulin resistance. The contributions of individual adipokines to the pathophysiological features of cardiometabolic diseases remain controversial.

Aims: To evaluate the association of adipokines and insulin resistance in young individuals with various metabolic phenotypes.

Methods: A cross-sectional study included 251 patients: group 1 – healthy metabolic profile with normal body weight (n=62); group 2 – unhealthy metabolic profile with normal body weight (n=57); group 3 - healthy metabolic profile and obesity (n=16); group 4 - unhealthy metabolic profile and obesity (n=116). Statistical significance was defined as p< 0.05.

Results: Individuals with unhealthy metabolic profile and obesity had the highest serum levels of leptin, plasminogen activator inhibitor-1 (PAI-1) and angiotensin II and the lowest serum levels of adiponectin. Overall, there was a significant relationship between the concentration of PAI-1 and insulin (Spearman r=0.345, p=0.01), PAI-1 and HOMA-IR index (Spearman r=0.251, p=0.06) among metabolically unhealthy obese individuals. The most significant linear correlations among metabolically unhealthy individuals with normal body weight were obtained between PAI-1 and angiotensin II (Spearman r=0.484, p=0.03), PAI-1 and endothelin-1 (Spearman r= - 0.462, p=0.04).

Conclusion(s): Understanding of the diverse effects of distinct adipokines and their interactions is still incomplete. Unraveling the pathophysiological roles of adipokines in young individuals with various metabolic phenotypes likely will result in a new personalized therapy strategy.