PB0987 - Impact of amotosalen/UVA process for pathogen reduction in platelet concentrates on transfusion efficiency in cardiac surgery

Tuesday, July 12, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: In-Person

Co-Author(s)

BB

Bouali Belkacem

Senior Scientist
Department of Cardiovascular, University Hospital of Saint-Etienne, France
Saint-Etienne, Rhone-Alpes, France
HH

Hind Hamzeh-Cognasse

Senior Scientist
SAINBIOSE Laboratory, INSERM, U1059, University of Lyon, Saint-Étienne
Saint-Etienne, Rhone-Alpes, France
AD

Anne Claire Duchez

Senior Scientist
Etablissement Français du Sang Auvergne-Rhône-Alpes & INSERM U1059
Decines-Charpieu, Rhone-Alpes, France
ME

Marie Ange Eyraud

Technician
Etablissement Français du Sang Auvergne-Rhône-Alpes
Decines-Charpieu, Rhone-Alpes, France
CA

Charles Antoine Arthaud

Technician
Etablissement Français du Sang Auvergne-Rhône-Alpes
Decines-Charpieu, Rhone-Alpes, France
AP

Amélie Prier

Technician
Etablissement Français du Sang Auvergne-Rhône-Alpes
Decines-Chapieu, Rhone-Alpes, France
EA

Estelle Audoux

Senior Scientist
Etablissement Français du Sang Auvergne-Rhône-Alpes & INSERM 1059
Decines-Charpieu, Rhone-Alpes, France
TE

Theo Ebermeyer

PhD student
SAINBIOSE Laboratory, INSERM, U1059, University of Lyon, Saint-Étienne, France
Saint-Étienne, Rhone-Alpes, France
PC

Patricia Chavarin

Senior Scientist
Etablissement Français du Sang Auvergne-Rhône-Alpes
Decines-Charpieu, Rhone-Alpes, France
AK

Azarnoush Kazra

Senior Scientist
Department of Cardiovascular, University Hospital of Saint-Etienne, France
Saint-Etienne, Rhone-Alpes, France
JM

Jérome Morel

Senior Scientist
Department of Anesthesiology and Intensive Care, Etienne University Hospital, Jean-Monnet University, Saint-Etienne, France
Saint-Etienne, Rhone-Alpes, France
JP

Jean Charles Palao

Senior Scientist
Department of Anesthesiology and Intensive Care, Etienne University Hospital, Jean-Monnet University, Saint-Etienne, France
Saint-Etienne, Rhone-Alpes, France

Presenting Author(s)

FC

Fabrice Cognasse

Senior Scientist, Director for Scientific Affairs
Etablissement Français du Sang Auvergne-Rhône-Alpes & INSERM 1059
Decines-Charpieu, Rhone-Alpes, France

Background: One of the most recent advances to improve blood safety and lower the risk of transfusion-transmitted diseases is the pathogen reduction treatment (PRT) of platelet concentrates (PCs). The characteristics of PR-treated PCs slightly differ from those of untreated PCs, and may affect transfusion outcome.

Aims: The aim of this research project is to see how effective amotosalen/UVA (INTERCEPT TM Blood System) PCs are when transfused to a group of cardiac surgery patients.

Methods: This study examined the influence of the PRT using amotosalen‐HCl and UVA light in a population of cardiac surgery patients.We analyzed the bleeding and platelet drop postoperatively in cardiac surgery with extracorporeal circulation. We selected 73 PCs after taking into account the medical exclusion criteria: 46 PCs without pathogen reduction treatment/Intercept® versus 27 PCs with pathogen reduction treatment/Intercept®.

Results: The decrease of patient platelet count between preoperative and H0 (start of surgery), preoperative and H6 (6 hours after) did not differ significantly with or without PRT. The volume of postoperative bleeding from cardiac surgery under extracorporeal circulation did not differ significantly regardless on whether the patient was transfused with PRT-PC or untreated PC. No difference was found in the number of postoperative pneumopathies between the groups. Moreover, independently of the use of PRT for platelets we observed an inverse correlation between preoperative fibrinogen and bleeding at 24 hours (post-surgery). A 1 mg/L increase in fibrinogen (preoperative) is associated with a 159 mL decrease in bleeding 24 hours after the start of the surgery.

Conclusion(s): In postoperative cardiac surgery, the use of platelets treated with amotosalen/UVA (INTERCEPT TM Blood System) for pathogen reduction does not appear to affect transfusion effectiveness and postoperative bleeding.