PB0037 - Association of the FVIII/DD and FvW/DD indices as an indicator of severity and mortality in patients with COVID-19

Sunday, July 10, 2022

6:30 PM – 7:30 PM

Location: Exhibition

Presentation Format: Virtual

Presenting Author(s)

Brenda Sarai Z. Ascencio, licenciatura en química clínica

Laboratorio trombosis
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico

Co-Author(s)

mj

maría esther E. jaime Capetillo

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
FV

Fernando V. Vidal Martínez

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
MC

Manuel de Jesús J. Castillejos Lopez

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
pM

patricia Martel Palomo

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
AC

Armando Castorena maldonado

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
lf

liliana figueroa Hernández

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
MR

María del Rosario R. Robledo Díaz

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
JM

Jesús Martínez de Rafael

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico
nR

natyelly Itzel I. Ruíz Gómez

coautor
INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS
Mexico, Distrito Federal, Mexico

Background: There are different studies on severity and mortality indices, such as the neutrophil/lymphocyte ratio (NLI), which has been relevant as a biomarker for mortality. However, indices where hemostatic factors are present, such as the FVIII/DD and FvW/DD ratio, have not been established for mortality in the Mexican population.

Aims: To determine whether the factor VIII and D-dimer (FVIII/DD) and the von Willebrand factor (VWF/DD) indices can be useful as markers of poor prognosis and mortality and to identify patients with a poor prognosis in cases of COVID-19 hospitalized from the National Institute of Respiratory Diseases.

Methods: A prospective, longitudinal study was carried out in which patients were admitted in the first 24 hours of hospitalization with a diagnosis of SARS-CoV-2 infection with a test confirmed by PCR; In a period from March to November 2020, laboratory data were recorded to generate the FVIII/DD and FvW/DD indices, including clinical, epidemiological data and discharge status.

Results: Data from 249 hospitalized patients with severe COVID-19 were analyzed. The clinical and laboratory characteristics are described in Table 1. The FVIIIDD24H and FVWDD24H indices were constructed by dividing each FVIII data by its corresponding DD data. and in the same way it was done with the VWF. The medians of these indices were then compared between the presence or absence of cyanosis, ventilatory status, and mortality. A value >115 was established as the cut-off point for the DD/FVIII and DD/FvW index to predict mortality, which are shown in Figure 1.

Conclusion(s): Low FVIIIDD24H and FVWDD24H levels on admission were associated with cianosis, severe COVID-19 and mortality. Likewise, it was shown that the cut-off point < or equal to 115 is a prognostic factor for mortality in this cohort of patients hospitalized for covid-19.