PO0023 - The potential differential diagnosis value of lymphocyte ratio in patients with cytopenic diseases

Wednesday, July 13, 2022

1:00 PM – 2:00 PM

Location: ExCel Center, ICC Capital Suite Room 1

Presenting Author(s)

Yueyi Xu, Master of medicine

Physician-in-charge
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China (People's Republic)

Co-Author(s)

Rongfu Zhou

Dr.
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China (People's Republic)

Background: The cytopenic diseases such as aplastic anemia (AA), myelodysplastic syndrome (MDS) and primary immune thrombocytopenia (ITP) sometimes have similar clinical and laboratory manifestation, which bring difficulties to clinical differential diagnosis. Therefore, it is necessary to explore new reference indicators conductive to differential diagnosis.

Aims: To explore the value of neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) , and platelet to lymphocyte ratio (PLR) in the differential diagnosis of cytopenic diseases.

Methods: The clinical and laboratory data of 105 patients with AA, MDS and ITP from 2017 to 2020 were retrospectively analyzed.

Results: The means of NLR level in AA, MDS and ITP groups were 0.631±0.414、1.285±1.165、3.527±2.033, respectively, the difference was statistically significant (F=35.82，P < 0.001). The three groups were sequentially compared in pairs, and the differences within the groups were statistically significant (P < 0.001). The NLR level of hypoplastic MDS (hypo-MDS) group was lower than that of non-hypo-MDS group, although there was no significant difference between these two groups, the NLR level of hypo-MDS group was closer to AA group (P>0.05). The MLR levels of these three groups were 0.114±0.099, 0.316±0.297 and 0.275±0.136, respectively (F=6.584，P=0.002). The MLR level of AA group was significantly lower than that of both MDS group and ITP group (P < 0.05), while there was no significant difference between MDS group and ITP group (P>0.05). Similarly, the MLR level of hypo-MDS group was lower than that of non-hypo-MDS group, while the former was closer to AA group. The PLR levels of these three groups were 16.718±23.322, 87.628±155.335 and 10.972±18.697, respectively (F=5.689，P=0.001). The PLR level of MDS group was significantly higher than that of both AA group and ITP group (P < 0.05).

Conclusion(s): There are differences in NLR, MLR and PLR levels among AA, MDS and ITP patients, which may have certain reference value for differential diagnosis of the three diseases.