PO0041 - Value of rotational thrombelastometry in perioperative management of patients with inherited coagulopathy during surgery

Wednesday, July 13, 2022

1:00 PM – 2:00 PM

Location: ExCel Center, ICC Capital Suite Room 1

Presenting Author(s)

Miroslava Drotarova, MD

PhD. student
National Centre of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Slovakia
Martin, Zilina, Slovakia

Co-Author(s)

Tomas Simurda, MD, PhD.

physician
National Centre of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Slovakia
Martin, Zilina, Slovakia
Jana Zolkova, DSc, PhD

laboratory researcher
National Centre of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Slovakia
Martin, Zilina, Slovakia
Monika Brunclikova, MD

physician
National Centre of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Slovakia
Martin, Zilina, Slovakia
JS

Jan Stasko

university professor
National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusion Medicine, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia
Martin, Zilina, Slovakia
IS

Ingrid Skornova

Laboratory diagnostician
National Center of Hemostasis and Thrombosis, Department of Hematology and Transfusion Medicine, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia
Martin, Zilina, Slovakia
ZC

Zoltán Cibula

doctor
Jessenius Faculty of Medicine, University Hospital in Martin
Matin, Zilina, Slovakia
LN

Libor Nečas

doctor
Jessenius Faculty of Medicine, University Hospital in Martin
Martin, Zilina, Slovakia

Background: Severe joint degeneration is a common complication in patients suffering from inherited bleeding disorders. Rotational thromboelastometry (ROTEM) allows to monitor hemostatic treatment with the possibility of specific treatment intervention.

Aims: To highlight the importance of ROTEM.

Methods: We are reporting the perioperative management in 21- and 22-year old patients with von Willebrand disease type 3 (vWD) and severe hemophilia A (HemA) during ankle arthrodesis. Standard laboratory tests and ROTEM-guided therapy were used.

Results: To the patient with vWD there was preoperatively administered 30 IU/kg FVIII/vWF concentrate. The basal levels before substitution were: FVIII: 34%, vWF activity: 16%, vWF antigen: 30%, aPTT: 32.4s and clotting time (CT) of INTEM: 178s. After the surgery these levels were normalized: FVIII: 103.5%, vWF activity: 84%, VWF antigen: 138% and aPTT: 29.2s. During the first 48h after the surgery, the patient was administered 20IU/kg FVIII/vWF every 8h. The patient was discharged home after 96h with aPTT 26.8s and control CT of INTEM 148s.
To the patient with severe HemA there was preoperatively administered rFVIII 50 IU/kg. After the surgery, FVIII level was 78% and CT of INTEM was 255s. During the first 24h after the surgery, the patient was administered rFVIII 30 IU/kg every 8h. The FVIII level was maintained 89±1% and CT of INTEM 200±5s. On the 1st postoperative day, the rFVIII dose was changed to 35 IU/kg every 12h. FVIII level achieved 76-66% and CT of INTEM 174-181s. Based on the CT of INTEM and FVIII level, the rFVIII dose was reduced to 20 IU/kg every 12h. On the 7th postoperative day, the patient was discharged home with a FVIII level 52% and CT of INTEM 82s. Bleeding symptoms were not observed in both patients.

Conclusion(s): Combination of standard coagulation testing and ROTEM represents adequate method for designing perioperative management in patients with inherited bleeding disorders.