PO0049 - Effect of platelet-rich plasma in combination with autologous adipose- derived mesenchymal stem cell in treatment of calcaneal enthesophytes.

Background: Several systemic disorders are related to calcaneal enthesophytes, including psoriatic arthritis, rheumatoid arthritis and diffuse idiopathic skeletal hyperostosis. However, enthesophytes may also develop in response to local mechanical stresses and could be associated with significant pain and disability

Aims: Currently, regenerative medicine encompasses a new area of medical science that involves the functional restoration of tissues or organs. Indeed, there are two competitive technologies that can repair and restore damaged tissue: platelet-rich plasma (PRP) and mesenchymal stem cell (MSC) based therapies Currently, regenerative medicine encompasses a new area of medical science that involves the functional restoration of tissues or organs. Indeed, there are two competitive technologies that can repair and restore damaged tissue: platelet-rich plasma (PRP) and mesenchymal stem cell (MSC) based therapies. The ability of MSCs to differentiate along a mesodermal cell line and secrete various regenerative and anti-inflammatory bioactive molecules has led to their consideration as a future repair therapy. On the other hand, PRP is a blood component that contains higher than normal platelet concentrations and includes platelet-related growth factors and plasma-derived fibrinogen. Preclinical trials with MSCs and PRP have shown promising positive functional and structural results in various connective tissue disorders.

Methods: A 37 years old patient, presents with a clinical history of calcaneal enthesophytes. Subsequent formal X-rays showed evidence of mechanical irritation between the heel bone and the Achilles tendon. The patient underwent intracalcanous autologous platelets-rich plasma in combination with adipose-derived MSC therapy

Results: Following treatment, the patient reported a clear functional improvement with disappearance of pain. Repeat X-ray showed successful regeneration of the heel bone-like tissue.

Conclusion(s): Following treatment, the patient reported a clear functional improvement with disappearance of pain. Repeat X-ray showed successful regeneration of the heel bone-like tissue.