VPB1351 - The Manipal Deep Venous Thrombosis Registry: Clinical Characterization, Treatment Patterns and 2-year Outcomes of DVT Patients in India

Background: Deep vein thrombosis (DVT) is associated with significant morbidity and mortality due to its recurrence and complications. The recent substantial data on DVT and its complications and long-term outcomes are limited in India.

Aims: This Manipal DVT registry is describing the clinical characteristics, treatment patterns, and outcomes of DVT patients.

Methods: This is a retrospective observational registry study carried out on all patients with a diagnosis of DVT confirmed by Doppler ultrasonography between 2014 and 2018 in a tertiary care center in South India. We have followed up the patients for 2-years for the DVT-related outcomes and correlated with the risk factors.

Results: A total of 612 eligible patients of DVT were included with the mean age of 49.5±15.3 years. Among all, 420 (68.6%) were males and 192 (31.4%) were females. One hundred eleven (18%) patients who have had a previous history of DVT and hypertension, malignancy, trauma/surgery, and varicose veins were presented in 154 (25.2%), 44 (7.2%), 96 (15.7%), and 143 (23.4%) patients respectively. Four hundred forty-six (72.9%) and 96 (11.6%) patients received warfarin and newer oral anticoagulants (NOAC) respectively. In composite major adverse outcomes, pulmonary embolism 66 (10.8%) was major followed by DVT recurrence 33 (5.4%) and death 16 (2.6%). A total of 123 (20.1%) patients were readmitted with DVT-related complications. The previous history of DVT and malignancy and smoking were the significant risk factors associated with 2-year composite outcomes with a p-value < 0.05.

Conclusion(s): Manipal DVT registry provides information about risk factors, clinical presentation, and treatment of DVT. The previous history of DVT, smoking, and presence of varicose veins, discoloration of the limb is associated with increased risk of readmission, major adverse cardiovascular events (MACE), or death. Patients with DVT associated with malignancy have reduced survival.